Correlation Between B-type Brain Natriuretic Peptide,Interleukin-6 And High-sensitivity C-reactive Protein And Chronic Heart Failure

Objective:To investigate the clinical value of BNP,interleukin-6 and high-sensitivity C-reactive protein levels in patients with chronic heart failure.Methods: Retrospective analysis of 180 patients who were hospitalized for chronic heart failure during the heart center of the First Affiliated Hospital of Xinjiang Medical University from October 2016 to November 2018,and selected 60 patients who did not have heart failure in our hospital during the same period.The healthy subjects were used as the control group.The levels of serum B-type brain natriuretic peptide,interleukin-6,high-sensitivity C-reactive protein and ejection fraction EF were measured,and the correlation with chronic heart failure was analyzed.Result: The BNP,IL-6,hs-CRP and LVEF values in the observation group were compared with the control group,and the difference was statistically significant(P<0.05).Serum B-type natriuretic peptide,interleukin-6 and high-sensitivity C-reactive protein in the HFrEF group,HFmrEF group and HFpEF group were significantly different(P<0.05).BNP was positively correlated with IL-6 and hsCRP,and negatively correlated with LVEF(r=0.371,0.394,-0.433,P<0.001).Conclusion: The detection of three biomarkers,serum B-type brain natriuretic peptide,interleukin-6,and high-sensitivity C-reactive protein,can help clinically improve the diagnostic value of heart failure.