Association Analysis Between TRPC6 Gene Polymorphism And Atrial Fibrillation In Essential Hypertensive Patients

Objective: To investigate the association between TRPC6 gene polymorphism and atrial fibrillation in essential hypertensive patients.Methods: We selected the case-control study of two groups respectively,354 essential hypertensive patients with atrial fibrillation were selected as the experimental group and 483 essential hypertensive patients as the control group.Two SNPs(rs10501981 and rs3824934)of TRPC6 gene were selected and genotyped by mPCR and high-throughput sequencing.Results: There were significant differences in the distribution of rs10501981 alleles and dominant model(CC vs CG+GG)of TRPC6 gene between EH+AF group and EH group(P=0.046 and P=0.032,respectively).After adjusting for age,TG,LDL-C,logistic regression analysis showed that the distribution of dominant model(CC vs CG+GG)was still significantly different between two groups.CG+GG genotype was a risk factor for atrial fibrillation in essential hypertensive patients(OR:1.546,95%CI:1.014-2.356,P=0.043).While there was no significant difference in the distribution of rs3824934 genotypes and allele frequencies between the two groups.Conclusion: TRPC6 gene polymorphism is associated with atrial fibrillation in essential hypertensive patients,and the CG+GG genotype of rs10501981 variation may be a risk factor for atrial fibrillation in essential hypertensive patients.