Analysis Of Risk Factors And Adverse Outcomes Of Early-onset Severe Preeclampsia With Fetal Growth Restriction

Objective: To explore the adverse pregnancy outcome of early-onset severe preeclampsia with fetal growth restriction,and to explore the risk factors of preeclampsia with fetal growth restriction.Methods:A retrospective analysis was performed on 98 patients with early onset severe preeclampsia who were admitted to the first affiliated hospital of xinjiang medical university from January 2018 to October 2019 and delivered in our hospital.The general conditions,clinical examination indexes,maternal complications and neonatal outcomes of the two groups were analyzed.Results:There was no significant difference in age,body mass index,proportion of primiparas,proportion of regular examination and weeks of pregnancy between the restricted group and the unrestricted group(P>0.05).The number of weeks of pregnancy was statistically significant between the two groups(P<0.05).The comparison of platelet number,S/D ratio,d-dimer level and urinary protein level between the two groups was statistically significant(P<0.05).Logistic regression analysis showed that urinary protein(OR=1.014,P=0.028,95% CI:1.014-1.284)was a risk factor for early onset severe preeclampsia in pregnant women with fetal growth restriction.The comparison of maternal complications between the restricted group and the unrestricted group was not statistically significant(P > 0.05).Two groups in neonatal congenital heart disease,small necrotic enteritis,neonatal anemia,the comparison of neonatal sepsis,and neonatal death had no statistical significance(P> 0.05),the team of neonatal respiratory distress is significantly higher than the control group(P<0.05),the difference was statistically significant,the team of neonatal intracranial hemorrhage were higher than control group11 percentage(P<0.05),the difference was statistically significant.Conclusions:Pregnant women with early onset and severe preeclampsia with fetal growth restriction had earlier onset gestational age,higher d-dimer,S/D ratio,24-hour urinary protein quantification,and fewer platelets than those without fetal growth restriction.Elevated urinary protein levels is a risk factor for fetal growth restriction in women with preeclampsia.