| 1.Purpose To study the short-term effect of Taohong Siwu Decoction Combined with western medicine and Western medicine alone on patients with chronic internal carotid artery occlusion and recanalization.2 Methods The subjects of this study were selected from the patients who successfully received the interventional therapy of chronic internal carotid artery occlusion from July 2017 to December 2019 in Anhui Hospital of traditional Chinese medicine.The researchers collected the general data of the patients when they were admitted to the hospital,and analyzed the clinical and laboratory data before and 3 months after the intravascular intervention treatment with MR perfusion imaging,MRS scale and Mo CA scale.3 Results(1)In this paper,67 cases of successful interventional therapy of chronic internal carotid artery occlusion were selected as the experimental subjects.7 cases were dropped due to adverse reactions or failure to continue taking medicine during the treatment period,including 32 cases in the treatment group and 28 cases in the control group.(2)In the treatment group,the score of MRS scale(1.13 ± 0.91)was lower than that before operation(2.97 ± 0.69);in the treatment group,the improvement of the score of MRS scale(1.84 ± 0.68)was higher than that in the control group(1.28 ± 0.64),there was statistical difference(P < 0.05).(3)The score of Mo CA in the 90 days after operation in the treatment group(23.94 ±3.01)was higher than that before operation(19.50 ± 3.73);the improvement degree of Mo CA in the 90 days after operation in the treatment group(4.44 ± 2.34)was higherthan that in the control group(2.68 ± 2.02),there was statistical difference(P < 0.05).(4)TTP(occlusive side)and r TTP(12.79 ± 0.80,1.16 ± 0.07)in the treatment group were significantly lower than those in the preoperative group(19.52 ± 1.89,1.83 ±0.14),and the improvement of TTP(occlusive side)and r TTP(6.73 ± 1.84,0.67 ± 0.14)in the treatment group was significantly higher than that in the control group(3.79 ±1.42,0.41 ± 0.11),with statistical difference(P < 0.05).(5)The MTT(occlusive side)and r MTT(3.99 ± 0.32,1.14 ± 0.11)in the treatment group were significantly lower than those in the pre-operative group(7.15 ± 0.95,1.83± 0.14);the improvement degree of MTT(occlusive side)and r MTT(3.16 ± 0.95,0.69± 0.20)in the treatment group was significantly higher than that in the control group(2.28 ± 0.81,0.45 ± 0.18),and there was statistical difference(P < 0.05).(6)The CBF(occlusive side)and r CBF(45.77 ± 5.40,0.79 ± 0.10)in the treatment group were significantly higher than those before operation(25.67 ± 6.69,0.44 ± 0.10);the improvement degree of CBF(occlusive side)and r CBF(-20.10 ± 9.73,-0.35 ±0.16)in the treatment group was higher than that in the control group(-13.99 ± 2.72,-0.25 ± 0.03),with statistical difference(P < 0.05).(7)There was no significant change in CBV(occlusive side)and r CBV(3.41 ± 0.49,1.12 ± 0.11)in the treatment group compared with that before operation(3.56 ± 0.50,1.13 ± 0.11);there was no significant difference in the improvement degree of CBV(occlusive side)and r CBV(0.14 ± 0.12,0.01 ± 0.001)in the treatment group compared with that in the control group(0.16 ± 0.29,0.02 ± 0.09)(P < 0.05).4 Conclusion Taohong Siwu Decoction Combined with western medicine can significantly improve the symptoms and cognitive function of patients with chronic internal carotid artery occlusion after recanalization;it can significantly reduce the mean time to pass(MTT),time to peak(TTP),increase the cerebral blood flow(CBF),but the cerebral blood volume(CBV)has no significant change. |
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