| The secret Kazakh medicine Xuan Ling Huayu ointment is a clinical experience prescription of the Ili Kazakh Autonomous Prefecture Hospital of Traditional Chinese Medicine(In Xinjiang Uygur Autonomous Region).It is mainly composed of Faeces trogopterori,Corydalis Rhizoma,Rhei Radix et Rhizoma and other medicinal matirials.And it can relieve swelling and pain,activate circulation to remove blood stasis and promote bone healing.That is,the effective ointment could be the "Pearl" for traumatic swelling and pain as a external treatment.It is mainly applied to treat blood stasis and paralysis syndromes such as bruises and pain in the limbs,and the effect is obvious.Besides,the agate ointment has been proven in the clinic for many years and is welcomed by the majority of patients,there are more than 40000 users within the outpatient and ward patients,and no one has poisoning and severe allergic reactions.Generally,this subject contains the research of production technology,the quality standard research,the stability test,and the skin safety.It will provide the theoretical guidance for the development of stable,safe and effective Chinese medicine preparations.Study on preparation technology:According to the crushing characteristics of each medicinal flavor in the Kazakh medicine Xuan Ling Huayu ointment prescription,formulating its pre-treatment method of the medicinal materials,considering the selection of the whole mixture and combining the powder extraction rate.comparing the RSD values of the content of tetrahydropalmatine inside the powder with different mixing time,choosing to use The three-dimensional motion mixer to better mixing for 20 to 30 minutes.By comparing the physical properties of honey refining and its mixing characteristics with medicinal powder at different refining times,the relative density is 1.410 to 1.420,and the moisture content is 17.50%to 18.50%.The refining time is 15 to 20 minutes of smelting honey was used as a supplementary ingredient.The single factor and orthogonal L9(33)were used to investigate the effects of mixing time,mixing temperature,and mixing speed on the molding of Manao Gao,then,the mixing time could be confirmed as 30 minutes,and the mixing temperature is 100 degree centigrade,the speed can be 150 round per minutes.The final determination of the molding process is:the above eleven flavors would be crushed into fine powder,sieved,and mixed.Then,taking 714.3g of honey,100? heat preservation stirring for 30 minutes,and mixing them well to acquire 1000g finished product,hen splitting and packaging them.Study on quality standards:In order to control the quality of Kazakh medicine Xuan Ling Huayu ointment,the traits,identification,inspection and content determination would be nvestigated.The thin layer chromatograph method for Faeces trogopterori,Corydalis Rhizoma,Rhei Radix et Rhizoma,A ngelicae sinensis Radix,Psoraleae fructus,Notoginseng Radix et Rhizoma and Strychni semen,and the method for determining the content of tetrahydropalmatine in Kazakh medicine Xuan Ling Huayu ointment would be developed.Further,the quality standards draft will be established.Because there is currently no pharmacopoeia standard for Faeces trogopterori in the prescription,a thin-layer identification and content determination method for amentoflavone in Faeces trogopterori is established.Study on stability:According to the "Technical Guiding Principles for the Stability Research of Traditional Chinese Medicine and Natural Medicines",the stability of the preparations would be investigated.An accelerated stability test and a long-term test method will be used to conduct a preliminary stability investigation of the Kazakh medicine Xuan Ling Huayu ointment,and the results can show the stable quality of this product.Study on safety:The research is divided into rabbit intact skin acute toxicity test,rabbit skin irritation test and guinea pig skin allergy test.The experimental results could show that the preparation is non-toxic,non-irritating and non-allergenic to the skin. |
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