Correlation Analysis Of Vitamin A And E Levels In Children With Kawasaki Disease

Objective: The correlation between serum vitamin A and E levels in children with Kawasaki Disease was prospectively analyzed.Methods: Children aged 0-4 years from July 2017 to December 2018 in Children's Hospital of Chenzhou Hospital affiliated to Nanhua University were selected,Children admitted to the department of cardiovascular medicine for diagnosis of Kawasaki Disease and children admitted to the department of child health for physical examination were included in the study.Kawasaki Disease Children were divided into coronary artery lesion group and non-coronary artery lesion group according to the Z value.Serum levels of vitamin A and E in children were determined by HPLC-tandem mass spectrometry.The serum vitamin A and E levels in children with Kawasaki Disease and healthy children was compared,and the serum vitamin A and E levels in children with Kawasaki Disease was compared between the coronary artery lesion group and the non-coronary artery lesion group.Results:1.Among the 94 children included in the study,43 were in the Kawasaki Disease group,26 were male and 17 were female,with an average age of(1.64±0.99)years: among them,13 were in the coronary artery disease group,7 were male and 6 were female,with an average age of(1.28±0.95)years;30 were in the non-coronary artery disease group,19 were male and 11 were female,with an average age of(1.78±0.99)years.51 were in the healthy children group,32 were males and 19 were females,with an average age of(1.81±0.95)years.There was no significant difference in gender composition and age between the coronary lesion group and the non-coronary lesion group,the children with Kawasaki Disease and the healthy children(P > 0.05).2.(1)The levels of vitamin A in the Kawasaki Disease group were lower than those in the healthy children group,and the difference was significant(P < 0.05).There was no significant difference in vitamin E levels between the Kawasaki Disease group and the healthy children group(P>0.05).(2)There was no significant difference in serum vitamin A and E levels between the Kawasaki Disease coronary lesion group and the non-coronary lesion group(P> 0.05).3.Vitamin A deficiency rates are significantly higher than vitamin E deficiency rates(P < 0.05).4.The serum vitamin A deficiency rate of Kawasaki Disease group was higher than that of healthy children group,and the difference was significant(P<0.05).There was no significant difference in serum vitamin E deficiency rate between the Kawasaki Disease group and the healthy children group(P>0.05).Conclusions:1.Kawasaki Disease in children may be correlated with low serum VitA level,but not with serum VitE level.2.There was no significant correlation between coronary artery lesion and serum vitamin A deficiency in children with Kawasaki Disease.