Relationship Between High-risk HPV Infection And Cervical Cancer And SIL In Northeast Sichuan District

Objective:Through analyzing the high risk subtypes HPV infection of cervical cancer&cervical squamous intraepithelial lesions in Affiliated Hospital of North Sichuan Medical College,the relationship between cervical cancer&cervical squamous intraepithelial lesions and high-risk subtype HPV infection in Northeast Sichuan district was investigated.lt would provide a certain reference for the prevention and treatment of high-risk HPV infection in the district.Methods:We retrospectively collected outpatients and inpatients diagnosed as cervical cancer or cervical squamous intraepithelial lesion by pathology department and tested for high-risk HPV in laboratory in our hospital from January 2018 to June 2019.We used the high-risk HPV genotyping real time PCR kit for this test.According to the data human papillomavirus infection,pathological diagnosis and clinical stage,the relationship between high-risk HPV subtypes and cervical cancer&cervical squamous intraepithelial lesion was discussed.Results:1482 cases were collected,including 310 cases of cervical cancer,514 cases of cervical high-grade squamous intraepithelial lesions and 658 cases of cervical low-grade squamous intraepithelial lesions.Their average ages were 51.11,44.67 and 44.62.1.HPV infection rate were significantly different in different pathological diagnoses(P<0.001).HPV infection rate of cervical cancer group and HSIL group were statistically significant(P<0.001).The same was true for cervical cancer group and LSIL group,HSIL group and LSIL group.2.The most common types of HPV(contains multiple infections)of this data were type 16(484 cases),type 52(243 cases),type 58(240 cases),type 18(97 cases),type 33(95 cases).3.The most common types of HPV(contains multiple infections)of cervical cancer group were type 16(183 cases),type 18(31 cases),type 58(28 cases),type 52(22 cases),type 33(14 cases).The most common types of HPV(contains multiple infections)of cervical squamous cell carcinoma group were type 16(172 cases),type 58(28cases),type 52(22 cases),type 18(18 cases),type 33(14 cases).The most common types of HPV of HSIL group were type 16(213 cases),type 58(127 cases),type 52(103 cases),type 33(63 cases),type 51(26 cases).The most common types of HPV of LSIL group were type 52(118 cases),type 16(88 cases),type 58(85 cases),type 18(43 cases),type 39(40 cases).4.HPV single infection was higher than multiple infection in cervical cancer,HSIL and LSIL groups.The difference of single infection between the three groups was statistically significant(P=0.010).Type 16 single infection and multiple infection with type 16 were statistically significant difference between the three groups(P=0.001).5.HPV positive rate in different clinical stages cervical cancer were not statistically significant(P=0.968).HPV positive rate in different age groups cervical cancer were not statistically significant(P=0.072).6.Vaccines targeting HPV 16 and 18 subtypes can cover 82.21%of HPV positive patients with cervical cancer.Nine-valent vaccines(targeting HPV16、18、31、33、45、52 and 58 subtypes)can cover 96.05%of HPV positive patients with cervical cancer.It can cover 94.33%of HPV positive patients with HSIL.It can cover 74.07%of HPV positive patients with LSIL.Conclusions:1.The most common types of HPV in this study were type 16,52,58,18,33.2.The most common types of HPV of cervical cancer group were type16,18,58,52,33.The most common types of HPV of cervical squamous cell carcinoma group were type 16,58,52,18,33.The most common types of HPV of HSIL group were type 16,58,52,33,51.The most common types of HPV of LSIL group were type 52,16,58,18,39.3.HPV single infection rate was higher than multiple infection in the three groups,and the cervical cancer group has the highest.4.It is suggested that the HPV nine-valent vaccine should be preferred for the local population.