Study On The Correlation Between Chronic Hepatitis B And Metabolic Syndrome

Objective: 1.To compare the incidence of metabolic syndrome between patients with chronic hepatitis B and those without CHB.2.To explore the demographic characteristics of CHB patients combined with MetS,and the influence of MetS on liver function,hepatitis B viral load and non-invasive liver fibrosis index in CHB patients.3.To explore the risk factors leading to MetS in CHB patients.Methods: In strict accordance with the inclusion and exclusion criteria,343 patients with chronic hepatitis B diagnosed in our hospital from January 2015 to December 2018 were selected as the case group,and 350 physical examiners matching the age,gender and case group were randomly selected as the control group.Laboratory tests,imaging tests,smoking and drinking histories of blood lipids,fasting blood glucose,liver function,HBV DNA,body mass index and other factors were collected.SPSS 21.0 software was used to process the data.The chi-square test was used to compare counting data.The independent sample t test was used for those conforming to normal distribution,and the MannWhitney U test was used for those not conforming to normal distribution.Risk factors for MetS in CHB patients were investigated by binary Logistic regression analysis.Results: 1.The incidence of MetS in the case group(8.7%)was significantly lower than that in the control group(14.29%)(P < 0.05).The incidence of high levels of TG,hypertension and non-alcoholic fatty liver(NAFLD)in the case group was also lower than that in the control group,and the incidence of low levels of HDL was higher than that in the control group(P < 0.05),but there was no difference in the incidence of high blood glucose.There were statistically significant differences in TCHO,TG,LDL,FBG,ALT,AST,TBIL,GGT and ALP between the case group and the control group(all P < 0.05),but no difference in HDL.2.In the case group,17.02% of patients over 45 years old had MetS,and 5.62% of patients less than or equal to 45 years old had MetS,and there was a significant difference between them(P < 0.01).The incidence of CHB with MetS was not significantly different between the sexes.ALT,TBIL,GGT levels and APRI,Fib-4 and GPR scores of patients with MetS were all higher than those without MetS,with statistically significant differences(P < 0.05),but there was no statistically significant difference in viral load between the two groups(P > 0.05).3.Analysis of risk factors leading to CHB with MetS showed that TG,FBG,GGT and BMI had significant positive influence on MetS,while HDL had significant negative influence on MetS.Conclusion: 1.The incidence of MetS of CHB was lower than that of the control group.Patients with CHB over 45 years old were more likely to combine MetS,but there was no difference in gender.2.CHB patients often have lipid metabolism disorders,and those with MetS are more prone to liver function damage and liver fibrosis,but have no effect on viral load.3.TG,FBG,GGT and BMI are risk factors for MetS in CHB patients.