A Retrospective Study Of 67 Cases With Motor Neuron Disease

Background and Objective : Motor neuron disease(MND)is a group of progressive neurodegenerative diseases characterized by changes in upper motor neurons and lower motor neurons.At present,its etiology and pathogenesis have not been clearly stated.Motor neuron disease can be divided into four types:amyotrophic lateral sclerosis(ALS),primary lateral sclerosis(PLS),progressive muscular atrophy(PMA),and progressive bulbar paralysis(PBP),which is according to the differences in lesions and clinical manifestations.ALS is the most common type of MND.MND has high misdiagnosis rate as a result of its insidious onset,clinical manifestation with chronic progressive exacerbation and similarity,the characteristics of high lethality and bad prognosis.Some researches indicate that it is significant to slow the progression of MND,by getting early diagnosis and treatment,although there is no effective one.Thus,this article,a retrospective study of 67 cases with MND,which analyzes the characteristic of the disease in order to enhance the understanding of the disease and assist in the early diagnosis.Methods:It collects the clinical data of 67 patients,who were hospitalized in the first affiliated Hospital of China Medical University from February 2017 to February 2020,and diagnosed MND initially.The collected data was analyzed retrospectively by spss26.0 software.Results:A total of 67 mnd patients were collected in this research,which included 35 men and 32 women,and the ratio of men to women was about 1.09:1.The first onset age range of 67 mnd patients was(25~86)years old.The average age was(59.31±11.25)years old,and the peak of age range was(55-64)years old.The main course type was subacute course(2~12 months),and the average course was(21.03±44.27)months.In terms of past medical history,there were 22 cases of hypertension,16 cases of diabetes,9cases of cerebral infarction,12 cases of surgery,13 cases of trauma and 4 cases of occupied lesions.55 patients with limb onset accounted for 82.09% of the totality.ALS patients is the main type with 56 cases(85.71%),among the four disease types.All patients finished electromyography(EMG),which indicated extensive neurogenic damage.Neuroimaging examination,in addition to help diagnose,also suggests that MND patients may have different parts and degrees of brain atrophy.No obvious specificity was found in routine biochemical tests.Conclusion: 1?MND was more common in the male and sporadic ALS.The average age range of first onset was(59.31±11.25)years,and the peak range was(55-64)years.The main course of MND was subacute(2~12 months).There was no correlation between course and weight loss.2 ? The lesion of onset was more common in limbs,and the development of lesion has a certain direction.Different lesion of onset and developmental direction might indicate different prognosis.3?Neuroelectrophysiological and imaging examination was significant to MND diagnosis.Craniocerebral imaging suggested that MND patients may have different degrees and parts of brain atrophy.4?The mechanism and prognosis of the disease might be indicated by routine biochemical tests,without specific indexes.