Relationship Of Neutrophil-lymphocyte Ratio And Platelet-to-lymphocyte Ratio With Systemic Involvement In Children With Henoch-sch?nlein Purpura

Objective: To figure out the relationship of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)with systemic involvement in children with Henoch-Schonlein purpura(HSP).Methods: Laboratory data including routine blood test results,C-reactive protein(CRP)levels and erythrocyte sedimentation rate(ESR)were collected from 464 HSP patients and 230 healthy controls and retrospectively analyzed.NLR and PLR were calculated and compared.The indexes of children with or without systemic damage were also compared at the same time.Logistic regression analysis was used to estimate variables related to children with systemic involvement,and the receiver operating characteristic(ROC)curve was drawn to ensure the diagnostic and predictive efficacy of NLR,PLR and other variables.Results: NLR and PLR were both higher in patients with HSP than in healthy controls(P<0.05).NLR,PLR,NEU and CRP 1evels of children with systemic involvement were significantly higher(P<0.05),especially those with gastrointestinal tract involvement(P<0.05).NLR was significantly higher in HSP patients with gastrointestinal bleeding than in those without(P<0.05).Logistic regression analysis showed that NLR and PLR were both risk factor for systemic involvement in HSP children(P<0.05).The ROC curve revealed that the optimal cut-off point of NLR for predicting systemic involvement was 2.91,with the sensitivity and specificity being 47.8% and 74.6% respectively.Conclusion: Both NLR and PLR evidently increase in HSP child patients,especially in those with systemic involvement.NLR and PLR have certain clinical value for the prediction of HSP patients with gastrointestinal and systemic involvement.NLR may be a potential predictive indicator for the presence of gastrointestinal bleeding.