Study On The Difference Of Bacterial Composition Of Peritonitis Between Diabetic Nephropathy And Non-diabetic Nephropathy Patients On Peritoneal Dialysis

End stage renal disease(ESRD)mainly refers to the end stage of various chronic kidney diseases,which can be divided into diabetic nephropathy and non-diabetic nephropathy.Peritoneal dialysis has become an important renal replacement therapy because of its advantages of simple operation,low cost and maintenance of residual renal function.With the continuous development of peritoneal dialysis technology,peritoneal dialysis associated peritonitis is still the most common complication of peritoneal dialysis patients,and the types of peritonitis pathogens are closely related to the prognosis of peritoneal dialysis patients.Related reports,the risk of death of peritoneal dialysis patients with diabetic nephropathy is higher than that of peritoneal dialysis patients without diabetic nephropathy,so,whether there is a difference in the distribution of pathogenic bacteria in peritonitis between diabetic nephropathy and non-diabetic nephropathy,there are few related reports at present.Objective:The purpose of this study is to guide the use of antibiotics by retrospective analysis of the composition of pathogens in peritonitis of peritoneal dialysis patients in our hospital.Methods:A retrospective analysis of 100 patients with peritoneal dialysis associated peritonitis(PDAP)in our peritoneal dialysis center from 2016 to 2019 was made.According to the type of primary disease,they were divided into diabetic nephropathy(DN)group and non diabetic nephropathy(NDN)group.The sex,age,biochemical indicators(hemoglobin,albumin,creatinine,urea nitrogen,blood potassium,calcium,phosphorus)and pathogenic bacteria structure of the two groups were analyzed Whether there was difference in the ratio(P < 0.05 was statistically significant).Results:1?There was no significant difference in gender between the two groups(P > 0.05).The age of diabetic nephropathy group was(58.84±9.55)years old,which was statistically significant compared with non diabetic nephropathy group(P < 0.05);2?There were significant differences in blood pressure,albumin,creatinine,urea nitrogen and blood phosphorus between the two groups(P < 0.05);There was no significant difference in hemoglobin,blood calcium and blood potassium between the two groups(P > 0.05);3?The proportion of Gram-positive bacteria was 71.14% and 68.18% respectively in the bacterial culture results of the two groups,in which Staphylococcus epidermidis was the main bacteria in diabetic nephropathy group,and Staphylococcus auricularis was the main bacteria in non-diabetic nephropathy group;in the bacterial culture results of the two groups,the proportion of Gram-negative bacteria was 26.67% and 27.27% respectively,which were mainly Escherichia coli,and there was no significant difference between the two groups(P > 0.05).Conclusion:There was no significant difference between diabetic nephropathy and non diabetic nephropathy.Compared with non-diabetic nephropathy patients,diabetic nephropathy patients have higher serum phosphorus concentration,but lower serum albumin,creatinine and urea nitrogen concentration.