| Coronary artery disease,as a common disease in the clinic,has a high incidence,mainly referring to coronary atherosclerosis leading to vascular stenosis or occlusion,the patient's myocardial cell tissue in a long period of ischemia,hypoxia state of the disease.The morbidity and mortality of coronary heart disease are increasing year by year,which is one of the main causes of sudden death in middle-aged and elderly people in China,which seriously threatens human health.The traditional view is that coronary atherosclerosis is closely related to intravascular risk factors(hypertension,hyperlipidemia,hyperglycemia,etc.).In recent years,people have a new understanding of the relationship between adipose tissue,especially epicardial adipose tissue(EAT)and the occurrence of coronary heart disease.Related studies have shown that epicardial adipose tissue has important endocrine activity Many adipose factors are closely related to the occurrence and development of coronary heart disease,and have been recognized as an important risk factor for coronary atherosclerosis.Multislice spiral computed tomography(MSCT)and Coronary computed tomographic angiography(CCTA)can be used to measure epicardial adipose tissue and related values to predict the occurrence and development of coronary heart disease.Objectives: Epicardial adipose tissue volume(EATV)and related values were measured by MSCT to evaluate its relationship with coronary heart disease.Methods: Coronary computed tomographic angiography(CCTA)was performed on 687 patients with clinically suspected coronary heart disease,including 326 males and 361 females,aged 27-82 years,with an average age of 58.28±9.28 years.Height and weight of the patients were recorded and body mass index (BMI)was calculated.Epicardial adipose tissue volume(EATV),Pericardial adipose tissue volume(PATV),Left ventricular free wall thickness(LVWT),Right ventricular free wall thickness(RVWT),and coronary artery calcification(CAC)scores were measured using GE AW 4.7 post-processing software.Coronary arteriosclerosis and stenosis were also observed.1.According to the CCTA to judge the coronary artery stenosis,those who have stenosis ? 50% in any of the three main coronary arteries are included in the coronary heart disease group,and those with stenosis <50% are included in the control group.2.The degree of coronary artery stenosis is divided into 0% to 50%,?50% to <75%,and ?75%.Results: 1 Comparison of clinical and imaging characteristics between CAD group and Control group: compared with the Control group,the CAD group had more male patients[56.8%(147/326)vs 41.8%(179/361),P<0.05].The average age of the CAD group was older than the Control group,59.79 ± 8.7 years old vs 57.36 ± 9.5 years old,the difference was statistically significant(P<0.05).The EATV,PATV,LVWT,RVWT and CAC scores in the CAD group were significantly higher than those in the Control group,(108.00(82.13,144)cm~3 vs(102(76.10,131.75)cm~3,225(178,277)cm~3 vs 204.5(153.00,257.75)cm~3,4(3.1,5.1)mm vs 3.65(2.70,4.70)mm,6.2(4.7,8.3)mm vs 5.5(4.00,7.50)mm,76.1(5.6,293)vs 0(0,0,7.225),respectively,differences were statistically significant(all P<0.05).The weight and BMI of the CAD group were higher than those of the Control group,were 70(63,78)kg vs 68(60,75)kg,25.19(23.26,27.61)kg / m~2 vs 25.10(23.05,27.03)kg / m~2,the differences was not statistically significant(all P> 0.05).2 Correlation between EATV and BMI: The median EATV of 687 patients was 105.00(78.37,138)cm~3.The maximum and minimum values were 279 cm~3 and 13.86 cm~3.The median BMI is 25.10(23.05,27.34)kg / m~2,and the maximum and minimum values are 38.63 kg / m~2 and 15.05 kg / m~2.Spearman correlation analysis : EATV was positively correlated with BMI,with a correlation coefficient(Rs)of 0.362,the differences were statistically significant(P <0.001).3 Correlation analysis of EATV and PATV: Spearman correlation analysis showed that EATV was positively correlated with PATV(Rs=0.872),the differences were statistically significant(P <0.001).4 Correlation analysis between EATV,PATV,LVWT,RVWT and C AC scores: Spearman rank correlation analysis showed that there were n o correlation between EATV,PATV,LVWT,and RVWT and CAC score s in the CAD group(all P>0.05),EATV,PATV,and RVWT in the Co ntrol group were correlated with calcification scores(Rs = 0.136,Rs = 0.169,Rs = 0.130),and the differences were statistically significant(all P <0.05),while LVWT no correlation with CAC score(P = 0.124).5 The relationship between EATV,PATV,LVWT,and RVWT and the degree of coronary stenosis: in the 0% to 50% group,EATV is 102(76.1,131.75)cm~3,PATV is 204.5(153,257.75)cm~3,LVWT is 3.65(2.7,4.7)mm and RVWT is 5.5(4.00,7.50)mm;in the 50% to 75% group,EATV is 107(81.52,131.75)cm~3,PATV is 223.5(155,275)cm~3,LVWT is 3.9(2.9,4.9)mm and RVWT is 6.0(4.3,8.4)mm;in the ?75% group,EATV is 110.5(83.59,147.54)cm~3,PATV is 229(171,287.5)cm~3,LVWT is 4.3(3.1,5.2)mm and RVWT is 6.3(4.9,8.25)mm;Kruskal-Wallis analysis showed that there were significant differences in the rank mean values of the coronary stenosis group of EATV,PATV,LVWT,and RVWT(all P <0.05),so it can be considered that EATV,PATV,LVWT,and RVWT have significant differences with the degree of coronary stenosis.Conclusions: 1 EATV,PATV and epicardial fat thickness are positively correlated with the occurrence of coronary heart disease and can be used as effective predictors of coronary heart disease;2 There are significant differences between EATV,PATV and epicardial fat thickness and the degree of coronary artery stenosis,which can be used as predictors of the severity of coronary heart disease. |
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