Correlation Between S100A8/A9 Protein Level And Severity Of Coronary Artery Disease And Short-term Prognosis In Patients With Unstable Angina Pectoris

Objective: To investigate the correlation between serum S100A8/A9 protein level and severity of coronary artery disease before PCI and the relationship between S100A8/A9 protein level and short-term prognosis after PCI in patients with unstable angina pectoris.Methods: Coronary angiography was performed in 99 patients with unstable angina pectoris,of which 27 had normal coronary arteries(control group)and 72 patients with coronary artery disease(coronary artery disease group).Coronary artery disease components were classified as mild to moderate coronary according to the Gensini score.Arterial disease(Gensini score 1-59 points)in 43 cases(mild to moderate group),severe coronary artery disease(Gensini score ? 60 points)in 29 cases(severe group),clinical data of patients were recorded,and an enzyme-linked immunosorbent assay was used.Detection of serum S100A8 / A9 protein levels;Spearman correlation analysis method was used to analyze the correlation between S100A8 / A9 protein levels and Gensini scores;multivariate logistic regression analysis was used to analyze risk factors of severe coronary artery disease;COX regression model was used to analyze S100A8A9 patients before and after PCI The relationship between the level of change and short-term prognosis.Results: Serum S100A8 / A9 protein levels [628.800(359.900,1045.000)] ug / L)in patients with coronary artery disease before PCI were higher than those in the control group [362.300(230.800,558.500)] ug / L](P <0.05),severe lesions Serum S100A8 /A9 protein level [813.500(577.100,165.0000)ug / L] was higher in patients with mild and moderate lesions than [505.500(300.600,862.100)ug / L](P <0.05).The arterial disease group was positively correlated with the Gensini score(r = 0.3319,P =0.0044),and elevated S100A8 / A9 protein levels were independent risk factors for the severity of coronary artery disease(OR = 1.091,95% CI: 1.01 to 1.178,P =0.027);the S100A8 / A9 level after PCI increased by 5.8% for every 100 units of preoperatively increased risk of short-term major cardiovascular adverse events(HR= 1.058,P = 0.002,95% CI: 1.021 ? 1.096).Conclusion: The level of S100A8/A9 protein in patients with unstable angina pectoris before coronary PCI is related to the severity of coronary artery disease.The level of S100A8/A9 protein changes before and after PCI is related to the short-term prognosis of patients with unstable angina.