The Mechanism Of Anti-myocardial Ischemia In Xinnaomaitong Capsule Based On Network Pharmacology

Objective:Xinnaomaitong capsule is a traditional Chinese medicine compound preparation made from the four flavors of Chinese herbal medicines:Lanwxiangchacai,Gegen,Danshen and Chuanxiong.The research method of network pharmacology further explores the mechanism of Xinnaomaitong capsules exerting anti-myocardial ischemic effects,and also provides a new perspective for the study of traditional Chinese medicine compounds.Methods:In this study,the chemical constituents of four Chinese medicines in Xinnaomaitong capsules were collected,and the active ingredients were screened based on the pharmacokinetic properties of the compounds.Targets of active compounds are predicted through the Swiss Target Prediction and TCMSP databases,and targets related to diseased myocardial ischemia are collected through Dis Ge Net.With the aid of the network visualization tool Cytoscape,a component-target network and protein interaction(PPI)network are established to establish drugs and Relationship between diseases.With the help of the DAVID database,the screening of Xinnaomaitong Capsules against myocardial ischemia was performed to enrich the target,and the mechanism of Xinnaomaitong Capsules was explored at the pathway level.Results: Among the four traditional Chinese medicines of Xinnaomaitong Capsules,9kinds of active ingredients were collected and screened from Lanexiangchacai,4 kinds of Gegen,61 kinds of Danshen,and 6 kinds of Chuanxiong.A total of 282 drug targets were obtained,and 446 myocardial defects were obtained.Blood targets,69 anti-myocardial ischemic targets of Xinnaomaitong Capsules were obtained.After enrichment analysis,they were related to 395 biological processes and 34 signal pathways.Conclusion:Xinnaomaitong Capsule may affect the occurrence of inflammation mainly by regulating TNF signal pathway and VEGF signal through IL-6,VEGFA,TNF,etc.,and promote angiogenesis,and then treat myocardial ischemia,showing its multicomponent-multitarget The characteristics of point effect,play a therapeutic role through the interaction between various targets.