Clinical Study On Yishen Antai Pills Intervening Pre-pregnancy And Preserving Post-pregnancy For Sequential Treatment Of Recurrent Spontaneous Abortion

Objective To investigate the clinical effect of Yishen Antai Pills on Pre-Pregnancy intervention and Post-Pregnancy Preserving sequential treatment of Patients with recurrent sPontaneous abortion(RSA).It is hoPed that through this study,more effective and safer treatment measures will be Provided for Patients with RSA,and a wider range of ideas and methods will be Provided for the clinical treatment of RSA.Methods Take the method of controlled research.The first is to observe the clinical efficacy of Western medicine routine treatment after Pregnancy for Patients who were naturally conceived without intervention before Pregnancy.The second is to observe the clinical effect of Yishen Antai Pills combined with Western medicine after Pregnancy on the basis of the interventional treatment of Yishen Antai Pills before Pregnancy.90 Patients who met the diagnostic criteria for RSA were randomly divided into a control grouP and a treatment grouP,with 45 cases in each grou P.The Patients in the control grouP had no sPecial treatment before Pregnancy,and were naturally conceived under the guidance of the clinician.After Pregnancy,they were treated with asPirin and low molecular weight heParin sodium in the control grouP.Patients in the treatment grouP were given Yishen Antai Pills for Pre-Pregnancy intervention treatment 3 months before Pregnancy,and after Pregnancy,they were given Yishen Antai Pills combined with asPirin and low-molecular-weight he Parin sodium.Observe and comPare the Pregnancy outcome and adverse reactions of the two grouPs of Patients,the changes in the TCM sym Ptom score,indexing and efficacy of the two grouPs of Patients,the embryonic develoPment shown by B-ultrasound after Pregnancy,and the changes of serum ?-HCG and P after Pregnancy in both grouPs.Results(1)ComParing the general condition and condition of the two grouPs ofPatients,it was found that the two grou Ps of Patients were in the age,number of miscarriages,days of abortion,TCM sym Ptom score and index before Pregnancy,and the control grouP had the TCM syndrome score grou P before and during Pregnancy In comParison,the difference was not statistically significant(P>0.05),which shows that the cases of the two grouPs are comParable.(2)In terms of TCM sym Ptoms,the TCM syndrome scores before and during Pregnancy in the treatment grouP and the TCM syndrome scores during Pregnancy in both grouPs were statistically different(P< 0.05),and the treatment grouP was significantly lower than the control grouP,indicating the treatment grouP had significant effect.(3)In terms of B-ultrasound,the maximum diameter of the gestational sac of the treatment grouP was greater than that of the control grouP at the 6th,7th,and 8th week of Pregnancy,and the difference between the grouPs was statistically significant(P < 0.05);At the 8th week of Pregnancy,the detection rate of fetal heartbeat was higher in the treatment grouP than in the control grou P,the difference was statistically significant(P<0.05).(4)In terms of serum ?-HCG and P,the serum ?-HCG and P of the two grou Ps of Patients at 5weeks,6 weeks,and 8 weeks of Pregnancy were comPared,and the difference was statistically significant(P < 0.05).The serum ?-HCG value and P value of the treatment grouP were higher than that of the control grouP,and the value increased raPidly in the early stage after Pregnancy.There was no statistically significant difference in serum ?-HCG value and P value at 10 weeks of gestation(P>0.05).(5)ComParison of Pregnancy outcomes between the two grouPs.There were 40 live births in the treatment grouP,including 38 full-term births and 5 miscarriages.The fetal success rate was 84.44%,and the 12-week Pregnancy embryo survival rate was97.78%.32 cases,including 28 cases of full-term delivery,13 cases of miscarriage,the success rate of fetal Preservation was 71.11%,the survival rate of embryos at 12 weeks of gestation was 88.89%,the differences were statistically significant(P <0.05).(6)ComParison of adverse reactions between the two grouPs of Patients,the Pregnancy vomiting of the treatment grouP was significantly lower than that of the control grouP,the difference was statistically significant(P < 0.05);the dizziness,headache and abnormal liver function of the two grou Ps of Patients were not statistically significant(P >0.05).Conclusion Im Plementing Yishen Antai Pills for Pregnant women with recurrent miscarriage to intervene Pre-Pregnancy and Post-Pregnancy sequential treatment of Pregnancy has a significant effect,which can increase the chance of Pregnancy of the Patient,effectively reduce the TCM sym Ptom score,imProve the clinical sym Ptoms of TCM,at the same time,it can increase blood ?-HCG levels,further Promote embryonic develoPment,thereby reducing miscarriage rate and increasing live birth rate.The effect of Yishen Antai Pills on Pre-Pregnancy intervention and sequential treatment of Post-Pregnancy Preserving fetus is significantly better than conventional Post-Pregnancy western medicine treatment,which is worthy of clinical Promotion and aPPlication.