The Study Of Electrochemical Non-enzyme Glucose Sensor Based On Co/Ni Bimetals Ultrathin Metal-organic Frameworks Nanosheet

With the improvement of living standards,people's risk of diabetes also increases.Since the beginning of the 21st century,people have gradually begun to pay attention to the intake of sugar and the harm of excessive consumption of sugar to human body.Therefore,accurate detection of glucose concentration has always been an important research content in clinical medicine,biotechnology,food industry and other fields.Glucose concentrations of common detection methods at present is mainly implemented by the enzyme containing glucose electrochemical sensor.For the electronic devices which containing enzymes,poor chemical stability,strict conservation and application conditions become the obstacles of the widely used.Development of a stable,easy to save,use,and lower production costs non-enzyme electrochemical glucose sensor is a very effective solution.In recent years,due to MOFs varied morphologies,large specific surface area and regular pore structure.Moreover,some types of metal-organic-frameworks(MOFs)materials have a large number of unsaturated metal active sites,which make them have great application potential in the field of electrochemical sensing.In particular,cobalt and nickel-based organic metal-organic frameworks(MOFs)materials are used as electrode materials in enzyme-free electrochemical glucose sensors.In this paper,we explored the preparation of high-performance electrochemical glucose sensor without enzyme by using Co/Ni bimetallic metal-organic frameworks materials.The main researches are as follows three parts,1.Design and prepare Co/Ni bimetal metal-organic framework ultrathin nanosheet(UMOFNs);2.Construct Co/Ni UMOFNs enzyme-free electrochemical glucose sensor and evaluate its performance;3.Analyze the detection mechanism of Co/Ni UMOFNs enzyme-free electrochemical glucose sensor;Enzyme-free electrochemical glucose sensor has been successfully built based on Co-Ni2:1 UMOFNs material,which has high sensing sensitivity(2086.7?A/m M/cm~2),wide linear range(0.1?M-1.4 m M),lower detection limit(0.047?M)and good anti-jamming capability,to real human serum samples detection accuracy reached 90.3%.In this paper,the sensing mechanism of Co-Ni 2:1 UMOFNs materials was systematically analyzed and explored using density functional theory(DFT),indicating that the Co/Ni bimetal coupling synergistic effect is conducive to improving the electron transfer efficiency between the detector and the material,thus improving the performance of the electrochemical glucose sensor.The main research results in this paper provide a good experimental and theoretical reference for the further construction of a high quality electrochemical sensor without enzyme glucose,and the sensor constructed by this experiment also has a good application prospect.