Analysis Of Prognosis And Factors Related To Locoregional Recurrence After Breast Conserving Surgery And Modified Radical Mastectomy In Patients With Stage Ⅰ-Ⅱ Breast Cancer

Objective:To investigate the prognosis after breast-conserving surgery(BCS)and modified radical mastectomy(MRM)in patients with stage Ⅰ-Ⅱ primary breast cancer,and analyze the factors related to locoregional recurrence(LRR).Methods:Analyze the clinicopathological and prognostic data of 1,330 patients with stage Ⅰ-Ⅱ primary breast cancer who underwent surgical treatment in the First Affiliated Hospital of Chongqing Medical University from January 2011 to December 2014.The clinicopathological characteristics and prognostic differences of BCS group and MRM group were compared.Factors related to LRR were analyzed by subgroup.Results:The median follow-up time was 71(4-103)months.There was astatistically significant difference in locoregional recurrence-free survival(LRRFS)between the BCS group and MRM group(P < 0.01).However,there was no statistical difference between the two groups in terms of distant metastasis-free survival(DMFS)and disease-free survival(DFS)(P>0.05).Univariate analysis showed that HER-2 positive was a risk factor for LRR after BCS(P<0.05),and axillary lymph node metastasis was a risk factor for LRR after MRM(P<0.05).Conclusions:The results of this study showed that for patients with stage Ⅰ-Ⅱprimary breast cancer,although there was a significant difference in LRFRS between the BCS group and MRM group,there were no significant difference in DMFS and DFS between the two methods.Therefore,choosing appropriate patients with stage Ⅰ-Ⅱ breast cancer to give breast-conserving treatment is safe and feasible,and it could be used as a recommended treatment strategy.