The Impact Of Weight-reduction On Inhibitory Control On Obesity Evidence From An ERP Study

Background: Obesity is a health problem that people all over the world face together,and with the development of society and economy,the problem of obesity becomes more and more prominent.There is already evidence that obesity-induced metabolic disorders,dyslipidemia,and inflammation contribute to the development of multiple diseases and the impact on the nervous system also increase the prevalence of some major diseases,such as hypertension,type ii diabetes.In addition,obesity may affect the development of individual brain structure and cognitive function.Weight loss as a cornerstone of the treatment of obesity can be achieved by limiting a variety of interventions such as calories and physical exercise.Beneficial effects of weight loss on some cognitive domains in obese individuals.However,most of them are based on observational findings,with few longitudinal studies,and few studies have been conducted on changes in processing of food-related stimuli after weight loss,and the underlying brain mechanism for the effect of weight loss on inhibition remains unclear.Objective: To explore whether weight loss has improved both general and food inhibition in obese individuals;and to use ERP technology to further determine whether weight loss interventions for cognitive mechanisms have actually succeeded in enhancing inhibition,how the brain processing characteristics of inhibition in obese individuals may change after weight loss;Whether changes in body weight are associated with changes in inhibitory function.Method: Go/Nogo task was adapted and divided into food inhibition task,neutral inhibition task,classical inhibition task to measure the changes of weight loss inhibition function in obese individuals before and after weight loss.The correct accuracy under Nogo condition and the reaction time under Go condition as well as N2,P3 were used to measure the inhibition ability.First,the inhibition function of the experimental group(17 people)and the control group(15 people)before and after weight loss were compared to determine whether the inhibition function was improved,and then correlation analysis of weight and inhibition function.Results: 1.The behavioral results showed that there was no significant difference in reaction time and correct accuracy between the experimental group and the control group in the food inhibition task and the classical inhibition task.in the neutral inhibition task,the experimental group and the control group all had significant differences in the response of go to food stimulation,but the correct rate was not significantly different.2.the N2 component results showed that in the food inhibition task,the N2 amplitude measured after the two groups in the CPz was significantly greater than the pre-test.;In the neutral inhibition task,the processing speed of the conflict monitoring was reduced and the response speed was slower after weight loss in the experimental group.In the classical inhibition task,the N2 lantency in the top region of the experimental group was the shortest,and the processing speed was significantly increased.3.The results of P3 components showed that the post-test inhibition function of both groups increased in the food inhibition task.And the lantency of Nogo P3 after weight loss in obese individuals was significantly reduced in the mid-top region.In the neutral inhibition task,the P3 amplitude of the post-test of obese individuals was significantly higher than that of pre-test,and the lantency of P3 component increased in the middle-frontal region,indicating that the processing speed became slower,indicating that the post-loss response inhibition ability increased,but the processing speed became slower.In the classical inhibition task,A main effect was found in Nogo P3 amplitude.FCz showed significant lower P3 amplitude than others.4.The results of correlation analysis showed that in the frontal region,the changes of weight and BMI were positively correlated with the changes of n2 amplitude,while in the classical inhibition task,the changes of weight were positively correlated with the changes of p3 amplitudeConclusion:(1)The general inhibitory function and food-related inhibitory function of obese individuals were improved after weight loss.(2)There was a significant positive correlation between changes in body weight and BMI and changes in inhibitory function.