Study On Liver Regulation And Turbidity Elimination In Redducing Weight And Blood-Lipid

As the standard of living gradually improved,many people start eating too much fat.At the same time,there is also the lack of exercise due to work overload.These factors result in the prevalence of obesity,and obesity is one of the main factors for hyperlipemia It is known that hyperlipemia can lead to the development of serious health problems,such as:atherosclerosis, coronary heart disease,hypertensive disease,cardiovascular diseases,diabetes,fatty liver etc. Therefore,obesity and hyperlipemia have aroused great attention around the world.The pathogenesis of obesity is often associated with phlegm-heat congestion,qi stagnation, static blood,and dysfunctions of the liver,spleen and kidneys.Qi is disturbed due to failure of the liver to convey and disperse,in turn leading to the presence of phlegm dampness and static blood.When the liver qi is stagnated,it will invade the spleen.In addition,liver and kidneys are intimately related;insufficiency of liver blood can lead to kidney deficiency;therefore liver dysfunction is the main cause of obesity.The cause of hyperlipemia is similar to that of obesity, in which phlegm dampness(also known as phlegm turbidity) is the main pathogenesis.This is because unresolved phlegm dampness can bring about blood stasis and aggravated disharmony between bowels and visera;such reasoning is further proved by modern experimental and clinical studies in recent years.This suggests that regulating the liver and resolving turbidity are the essential ways of treating hyperlipemia and obesity.In the intervening time,additional supplementary treatments can be used concurrently;such as regulating spleen and kidneys, promoting qi to activate blood,drying dampness to eliminate phlegm,etc.Obesity is often diagnosed according to the international BMI(Body Mass Index),and the formula is:BMI=weight(kg)/height(meter)~2.In consideration of the Chinese race and body structure,the diagnostic standard is roughly:24 is the upper normal limit,24-28 is overweight, and＞28 is obesity.The diagnosis of hyperlipemia is based on blood biochemistry tests:the normal serum total cholesterol range(TC) for the Chinese is＜5.20mmol/L(200mg/dl),5.23～5.69mmol/L(201～219mg/dl) is the high edge,and＞5.72mmol/L(220mg/dl) is high.The normal level of triglyceride(TG) is＜1.70mmol/L(150mg/dl) and＞1.70mmol/L(150mg/dl) is high.For the lipoproteins,especially low density lipoprotein(LDL-C),the normal range is＜3.12 mmol/L(120mg/dl),3.15～3.61mmol/L(121～139mg/dl) is the high edge,and＞3.64mmol/L(140mg/dl)is high.The choice of treatment for obesity and hyperlipemia in TCM are abundant and diverse today,and they are mainly based on syndrome differentiation.Other ways such as acupuncture and tui-na are applied as well,and Chinese formulated products are also widely used in clinical settings because of their conveniency.In western medicine,there are several ways and measures in treating obesity:on the basis of an overall evaluation,diet adjustment and increase in mild sporting activities are initially introduced to the patient;furthermore behavior correction and psychological treatments may also be conducted.If these treatments are ineffective,that is when medication or surgery comes in. Medication for obesity can be divided into four groups:the first group isto depress appetite;the second group is to hamper absorption of the digestive tract;the third group is to hamper fat storage;the forth group isto accelerate fat metabolism.For the treatment of hyperlilpemia,it also begins with diet modification,then medication would be the next in line.Western medicine in the treatment of hyperlipemia are divided into six groups:the first is hydroxy-methyl-glutaryl coenzyme A(HMG-CoA) reductase inhibitor;the second is androtor and phenoxy acetic acid (also called fibrates);the third is cholic acid combined resin;the forth is nicotinic acid and its derivates;the fifth is fish oil w-3 fatty acid;and the sixth are other drugs including elastase, probucol,pantethine etc.Although TCM and western medicine both contain many strategies and drugs in treating obesity and hyperlipemia,there are many imperfections and problems.For example the standard on obesity,issues associated with treating obesity and hyperlipemia,and the normalization of TCM in the section of hyperlipemia.To overcome the above problems,my thesis is to design simple products or recipes to reduce weight and blood-lipids on the basis of liver regulation and turbidity elimination.Other treatments such as spleen and kidney tonifications,and blood activation are used in conjugation. There are four products:1.Five element ferment seed granule meal replacing pack:plantain seed,radish seed,white mustard seed,great burdock achene,cassia seed,mung bean,hosie ormosia seed,white hyacinth bean,black been,soybean,black sesame,walnut oil flour,elephant-foot yam flour,spirulina,oat, five elements ferment,and Japan agar flour.Black sesame isthe principal drug in the Five element ferment seed powder replacing meal pack.It is used for the purpose of liver and kidney tonifications;it can also lubricate the intestines to promote defecation,and decrease fat absorption to achieve weight and blood-lipid reductions,When walnut oil is used in conjunction with black sesame,it can further lubricate the intestine to relieve constipation,and invigorate the liver and kidneys.Elephant-foot yam flour and oat are both nutritional foods;they can supply nutrition,and reduce weight and blood-lipids. Spirulina is commonly used to reduce weight and blood-lipids.All of the above,except for black sesame,are ministerial drugs.The ten herbs below are adjunctive drugs.Jumble bead,mung bean,soybean,white hyacinth bean and black bean are of five different colors,and each of them enters into one of the five visceral organs:heart,liver,spleen,lungs and kidneys.Plantain seed enters the kidney meridian,radish seed enters the heart meridian,white mustard seed enters the lung meridian,great burdock achene enters the spleen meridian,and cassia seed enters into the liver meridian;furthermore each of the five seeds also enters into a corresponding visceral organ. All together,they can nourish the body and regulate the five visceral organs.In addition,when the five visceral organs are in harmony,smooth qi-blood circulation can be achieved,and phlegm turbidity,static blood,and surplus fat can all be resolved spontaneously.The five element ferment and Japan agar flour are responsible for the coordination of this prescription; and therefore are the messenger drugs.This prescription can replace meals to provide nutrition; in addition it can reduce weight and blood-lipids(through lubrication of the intestines,not strong purgation) of the patient.This prescription can also invigorate the liver and kidneys,coordinate the five visceral organs,drain dampness and resolve phlegm,and disperse depressed liver qi in order to treat both the superfidal and root causes.All together,reductions in weight and blood-lipids can be achieved.2.Liver soothing and toxin detoxifying capsule:curcuma,bupleuri,artemisiae capillaries, cape jasmine fruit,andrographitis,hedyotic diffusa,rabbit vegetable,plantain seed,oriental waterplantain rhizome,rehmannia dride rhizome,Chinese Angelica,Agastache rugosa.In the liver soothing and toxin detoxifying capsule,curcuma is the principal drug,which promotes qi,activates blood,and can enter into the liver meridian.Not only does it soothe the liver and moves qi,but can also activate blood and resolve stagnation;therefore it is a good herb in treating qi stagnation and static blood.Bupleuri disperses depressed liver qi.Curcuma assists the principle drug in soothing the liver and moving qi because its pungent taste can relieve the exterior and disperse hepatic fire.Cape jasmine fruit and artemisiae capillaries contribute to additive efficacy in clearing and dispersing hepatic fire.Andrographitis,hedyotic diffusa,rabbit vegetable all can deer heat and resolve toxin,and they are ministerial drugs.Rehmannia dride rhizome and Chinese angelica activate and soothe blood,and when they are accompanied by curcuma,their blood activating effect can be enhanced without damaging the blood.Plantain seed,oriental water plantain rhizome and Agastache rugosa are adjunctive drugs,and they can drain dampness and resolve turbidity.This prescription mainly soothes the liver,purges fire, dears heat,resolves toxin,activates blood and drains dampness.3.Liver qi regulating capsule:curcuma,artemisiae capillaries,danshen root,cape jasmine fruit,Chinese magnoliavine fruit and ophiopogonis tuber.Curcuma is heavily used in this prescription to soothe the liver and regulate qi,activate blood and resolve stasis;therefore it is the principal drug.Artemsiae capillary can assist the principal drug to soothe the liver,and danshen root can help the principal drug to activate blood and resolve stasis;therefore they are both ministerial drugs.The following herbs are all adjunctive drugs:cape jasmine fruit can clear heat and hepatic fire due to liver depression; ophiopogonis tuber nourishes yin;Chinese magnoliavine fruit is a sour and astringent herb which prevents curcuma and artemisiae from damaging the right qi,and since it is acidic,it can enter into the liver to reinforce it.This prescription mainly soothes the liver,and dears heat and activates blood simultaneously.4.Blood-lipid redudng capsule:red rice,common yan rhizome,hawthorn,Chinese angelica, szechwan lovage rhizome,peach seed,prepared dried ginger,radix glycyrrhizae,manyprickle acanthopanax root,mulberry leaves and gold theragran.In our products,the five element ferment seed granule meal replacing pack mainly invigorates the liver and kidneys.Patients can take it in place of meals,which would be able to supply them the required nutrition and energy,and at the same time reduce weight and blood-lipids.It is a simple and convenient way for patients to lose weight.It is suited for obesity and lipidemia,and its benefits also indude liver invigoration.Liver soothing and toxin detoxifying capsule mainly soothes the liver and purges fire.It has curative effects for fire toxin and qi stagnation due to liver depression in obese patients,Both prescriptions disperse the liver as the main strategy of treatments.Blood-lipid reducing capsule mainly resolves turbidity,invigorates the spleen,and activates blood to dissipate static blood;therefore it suits patients that have spleen asthenia with turbid dampness.The above serial products embody the method of adjusting the liver and resolving turbidity to reduce weight and blood-lipids.All of the above products are proven to be safe in genotoxicity experiments,animal trials and liver function tests.