The Correlation Among Bodyweight,Lung Function And Cardiac Structure In Elderly Patients With Chronic Obstructive Pulmonary Disease

Objective: To explore the correlation among bodyweight,lung function and cardiac structure in elderly patients with chronic obstructive pulmonary disease(COPD).Methods: A total of 747 elderly patients ≥65 years were retrospectively collected,including 184 cases in non-COPD group,77 cases in mild COPD group,206 cases in moderate COPD group,280 cases in severe COPD group.Body mass index(BMI),lung function and cardiac structure in patients were detected.Comparison and correlation regression analysis of relevant parameters were performed among groups.Results: The main findings of this study:compared with non-COPD group,in severe COPD group,the right ventricular diameter(RVD)increased significantly(P < 0.05),the BMI,left atrial diameter(LAD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular mass index(LVMI)decreased significantly(P < 0.05),while the RVD,BMI,LAD,IVST,LVPWT,LVMI in the mild to moderate COPD group was not significantly different fromthat in the non-COPD group.Correlation analysis found that in severe COPD group,low BMI was significantly correlated with the increase of residual volume / total lung capacity(RV / TLC),RVD,right atrial diameter(RAD),high-density lipoprotein cholesterol(HDL-C),estimated glomerular filtration rate(eGFR)(P < 0.05),while low BMI was significantly correlated with the decrease of forced expiratory volume in one second as a percentage of predicted value(FEV1 % pred),forced expiratory volume in one second /forced vital capacity(FEV1 / FVC),diffusion capacity for carbon monoxide(DLCO),LAD,IVST,LVPWT,LVMI,plasma albumin,hypertension,systolic blood pressure,type 2 diabetes mellitus,total cholesterol(TC),uric acid(UA)(P < 0.05).Regression analysis found that in severe COPD,low BMI was independently correlated with increased RVD(P < 0.05),while was independently correlated with decreased FEV1%pred,IVST,LVPWT,LVMI(P < 0.05).Conclusion: Low body mass index was independently correlated with lung function impairment,right ventricular enlargement and left ventricular mass index reduction in elderly patients with severe COPD.