A Study Of Serum Cartilage Oligomeric Matrix Protein In Patients With Ankylosing Spondylitis

ObjectiveAnkylosing spondylitis(AS)is an autoimmune inflammatory disease involving axis bone,sacroiliac joint and/or peripheral joint,which may be accompanied by extraarticular manifestations.The disease is most common in young men,with atypical early symptoms,long duration of disease course and uncontrollable disease condition.The AS patients often see the doctor because of pain,spinal joint deformity and limited function,which can cause serious social and economic burden.Therefore,early diagnosis and monitoring of inflammation and disease activity are of great importance.The main pathological changes of AS are synovitis,cartilage degeneration and destruction.Serum cartilage oligomeric matrix protein(COMP)is a marker of cartilage metabolism.Some scholars have proved that serum COMP level can reflect cartilage injury and synovitis in the research of rheumatoid arthritis(RA)and osteoarthritis(OA),but there is little research on AS.This article will discuss the level of COMP in serum of AS patients and its correlation with disease activity.MethodsThis study collected 60 patients with ankylosing spondylitis,including 30 patients in active group(BASDAI score ? 4),30 patients in inactive group and 30 patients in healthy control group.ELISA was used to detect the COMP concentration in serum of AS patients,healthy control group and 12 active patients of the AS before and after treatment for 24 weeks.At the same time,the levels of erythrocyte sedimentation rate,C-reactive protein,platelet,tumor necrosis factor ? and globulin in patients' serum were detected,and sacroiliac joint CT grading was performed.SPSS22.0 statistical software was used to analyze the serum COMP level in active group,inactive group and healthy control group,and the correlation between serum COMP and age,course of disease,erythrocyte sedimentation rate,C-reactive protein,platelet,tumor necrosis factor ?,globulin and sacroiliac joint CT grade was analyzed.ResultsThe COMP level in the AS active group was(79.29±13.98)ng/ml,in the inactive group was(67.69±13.92)ng/ml,and that in the healthy control group was(55.49±10.63)ng/ml.The serum COMP level in the active group was higher than that in the inactive group and the healthy control group,with statistically significant difference(p < 0.05).The serum COMP level in the inactive group was higher than that in the healthy patients,with statistically significant difference(p < 0.05).The average COMP level of 12 AS active patients was(81.23±13.22)ng/ml before treatment and(67.03±10.93)ng/ml after treatment,with statistically significant difference(p < 0.05).Correlation analysis showed that serum COMP level was positively correlated with BASDAI and VAS of spinal pain(p < 0.05),but was not significantly correlated with age,course of disease,erythrocyte sedimentation rate,C-reactive protein,platelet,globulin and CT grade(p > 0.05).ConclusionsSerum COMP can reflect inflammation and disease activity of AS patients,can be used as a reference index for AS curative effect.Combined with serum C-reactive protein and erythrocyte sedimentation rate results,it can better evaluate inflammation reaction,disease activity and guide treatment of AS patients.