| Background and purpose:Biodegradable polymer and polymer-free drug-eluting stents are new generation drug-eluting stents which were introduced to reduce in-stent restenosis and stent thrombosis that probably triggered by permanent polymer.Although many trials demonstrates they are non-inferior to permanent drug-eluting stents,there are limited data about their clinical outcomes in the treatment of unprotected left main lesions.This study aims to evaluate the safety and efficacy of different kinds of polymer drug-eluting stents for unprotected left main lesion PCI.Methods:This study analyzed those patients who were diagnosed with UPLM by coronary angiography and underwent percutaneous coronary intervention(PCI).They were divided into 3 groups according to the different stent-type: permanent(PP-DES),biodegradable(BP-DES)and polymer-free(PF-DES)group.All the patients were followed up for 12 months.The primary clinical outcome was target vessel failure(TVF)including target vessel myocardial infarction(TVMI)and target vessel revascularization(TVR).The secondary clinical outcome was major adverse cardiovascular events(MACE)including cardiac death(CD),nonfatal myocardial infarction(NFMI)and any revascularization.Results:1.This study analyzed 259 cases including 153 in PP-DES group,54 in BP-DES group and 52 in PF-DES group.2.There were no significant differences in clinical and procedural characteristics among 3 groups(p>0.05).3.There were no significant differences in the risks of TVF(PP-DES 7.2% vs BP-DES 1.9% vs PF-DES 2.0%,p=0.227)and MACE(PP-DES 17.6% vs BP-DES 9.3% vs PF-DES 9.6%,p=0.210)among 3 groups.There were no significant differences in cumulative incidence of TVF(log-rank p=0.079)and MACE(log-rank p=0.096)among 3 groups.Conclusions:The safety and efficacy of biodegradable polymer and polymer-free DES for unprotected left main lesion are comparable to permanent polymer DES. |
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