Investigation And Analysis Of Iodine Nutrient Status And Thyroid Dysfunction Among Adults In Baohe District Of Hefei City

ObjectiveTo investigate the status of iodine nutrition status and thyroid dysfunction of adults in Baohe District of Hefei City,and to explore the correlation between iodine nutrition level and thyroid dysfunction.MethodsFrom September 2016 to October 2016,this study adopted cluster and stratified sampling in Baohe District of Hefei City.A total of 2628 permanent residents over 18years old were selected;including 1331 urban residents and 1297 rural residents,aged between 18 and 95 years old,with an average age of(43.87±14.63).There were 1420males(54.03%),with an average age of(43.15±14.67)years old.There were 1208females(45.97%),with an average age of(44.72±14.53)years old.The morning fasting venous blood(10ml)of all subjects were obtained to detect the serum Free thyroxine(FT4)、Free triiodothyronine(FT3)、Thyroid stimulating hormone(TSH)、Thyroperoxidase antibody(TPOAb and Thyroglobulin antibody(TGAb)concentration by chemiluminescence immunoassay.The morning fasting urine(5ml)of all subjects were obtained to detect the urine iodine concentration by As3+-Ce4+catalytic spectrophotometry using ammonium persulfate digestion.Use SPSS 19.0 to do statistic analyze,the K-S test was used to test whether the quantitative data were normally distributed.Measured data with normal distribution was expressed as x±s,the non-normal distribution was expressed as[M(P25,P75)],and the composition ratio was represented by n(%).Comparison among normal distribution groups was conducted by Anova,Non-parametric rank sum test,and Chi-square test.Pearson analysis was used to compare the correlation between thyroid antibody and UI;Risk factors of thyroid disease were analyzed by logistic regression.P<0.05 was considered statistically significant.Results一、UI situation:The median UI of the total population was 209.67μg/L,291 cases in the iodine deficiency group(11.07%),941 cases in the iodine adequate group(35.81%),687 cases in the iodine super adequate group(26.14%),709 cases in the iodine excess group(26.98%).The median TSH of the total population was 2.63μIU/ml,the TSH of the four groups were 2.88(1.96~4.35)μIU/ml,2.60(1.81~3.84)μIU/ml 2.58(1.79~3.71)μIU/ml,and 2.67(1.90~3.81)μIU/ml,There was no statistical significance between them(Z=7.512,P=0.057).The positive rates of TPOAb and TGAb in the total population were(238,9.06%)and(241,9.17%).The positive rates of of the four groups were(37,12.71%),(91,9.67%),(50,7.28%)and(60,8.46%),There was no statistical significance between them(X~2=8.101,P=0.040).The positive rates of TGAb were(45,15.46%),(84,8.93%),(47,6.84%)and(65,9.17%).The difference was statistically significant(X~2=18.379,P<0.001).二、Comparison between different genders:UI level 229.35(157.52~336.59)μg/L on male and 185.54(128.07~278.22)μg/L on female,there were statistically significant differences in UI level between male and female(Z=-8.736,P<0.001).The different of TSH values[2.50(1.74~3.58)μIU/ml vs 2.85(2.02~4.18)μIU/ml,Z=-6.555,P<0.001],the positive rate of TPOAb[72 cases,5.07%)vs(166,13.74%),X~2=59.590,P<0.001],and the positive rate of TGAb[(64,4.51%)vs(177,14.65%),X~2=77.850,P<0.001]between men and women were no statistically significant.三.Comparison between people living in different places:The different of UI level[214.05(146.65~315.67)μg/L vs 205.74(141.31~304.78)μg/L,Z=-0.333,P=0.739]、TPOAb positive rate[(115.8.10%)vs(123,10.18%),X~2=0.558,P=0.455]、TGAb positive rate[(125,9.39%)vs(116,8.94%),X~2=0.163,P=0.686]and TSH value[2.59(1.83~3.72)μIU/ml vs 2.71(1.85~3.90)μIU/ml,Z=-1.985,P=0.057]between urban and rural residents were no statistically significant.四、Characteristics of thyroid dysfunctions:There were 552 patients with thyroid dysfunctions,accounting for 21.00%of the total population;Subclinical hypothyroidism was the most common thyroid dysfunction,accounting for 19.25%(506 cases)of the total population.There were statistically significant differences in gender,TPOAb positive rate and TGAb positive rate among the different thyroid dysfunction groups(P<0.05):the proportion of women was higher than that of men,and the proportion of TPOAb and TGAb positive rate of thyroid dysfunction antibodies was higher than that of men with normal thyroid function.There was no statistically significant difference between urban and rural residents(P>0.05).UI level of hyperthyroidism group was highest than other groups(P<0.05).五、Comparison of UI level of thyroid antibody positive/negative group:UI level of TPOAb antibody positive was higher than that of negative group[211.52(145.23~312.25)μg/L VS 187.34(125.21~300.98)μg/L;(Z=-2.255,P=0.024)].UI level in TGAb positive group was higher than that in TGAb negative group[210.99(145.62~309.65)μg/L VS190.96(119.05~312.56)μg/L;(Z=-2.058,P=0.040)].UI level in the single antibody positive group was higher than that of double antibody positive group(135 cases)[211.69(145.62~311.11)μg/L VS 181.82(109.89~303.77)μg/L,(Z=-2.594,P=0.009)].六、Correlation analysis between thyroid antibody positive group and UI level:Pearson correlation analysis showed that there was no correlation between TPOAb、TGAb values and UI level in TPOAb positive group,TGAb positive group or double positive group.七、Multivariate logistic regression analysis showed that TPOAb positive、TGAb positive were important risk factors for Thyroid disease.Conclusion一、The general level of iodine nutrition in the participants is super excessive in Baohe District of Hefei City.二、The resident’s nutrition status of iodine in urban and rural roughly equivalent,But women were more likely to be iodine-deficient.三、Thyroid dysfunctions accounting for 21.00%of the total population,Subclinical hypothyroidism are common in population with thyroid dysfunction.四、UI level in the positive thyroid antibody group was higher than that of negative group,but there was no correlation between antibody value and UI level in positive thyroid antibodygroup.五.Positive thyroid autoantibody is a risk factor for thyroid dysfunction.