The Diagnostic Value Of Substantia Nigra Hyperechogenicity Of Transcranial Sonography In Parkinson's Disease

Objective:To determine the cutoff value of substantia nigra hyperechogenicity(SN+)quantitative index of Pakinson's diesase(PD)patients in our hospital,to evaluate and select the best diagnostic indicator,and to pay attention to whether SN+is stable in the disease.Methods:Transcranial sonography(TCS)examination was performed on 120 PD patients and150 healthy controls with matching age and sex distribution in the same period.The area of SN+and midbrain were measured,the S/M ratio was calculated.By statistical analysis,the optimal cutoff value of SN+area and S/M was determined,the diagnostic value of SN+area,S/M and SN+area combined with S/M was compared,and the correlation between SN+area and age and Hoehn and Yahr scale(H-Y sale)was analyzed.Results:37 Parkinson's patients and 35 healthy controls who could not complete the TCS examination due to unclear temporal sound window were excluded.Finally,a total of 83PD patients and 115 healthy controls were enrolled.The SN+area and S/M of PD patients and healthy controls were 0.23±0.07 cm~2 and 7.45±2.94%,0.11±0.06 cm~2and 3.77±2.35%,respectively.There are significant differences in comparisons.The optimal cutoff values of SN+area in PD patients is 0.18cm~2,with a sensitivity of 88%and a specificity of 88.7%;the optimal cutoff value of S/M is 7%,with a sensitivity of69.9%and a specificity of 91.3%;the sensitivity is 88%and the specificity is 94.8%when combined with SN+and S/M,respectively.By Pearsen correlation analysis,we found that SN+area had no correlation with age or H-Y scale.Conclusion:The SN+area cutoff value of PD patients in our hospital is 0.18cm~2 and the S/M cutoff value is 7%.Combined SN+with S/M during the evaluation is the best choice.SN+area had no correlation with age or H-Y scale,but the stability of SN+in PD patients needs further investigation.