Efficacy Of High Intensity Interval Training In Young Obese Patients With Type 2 Diabetes Mellitus

Objective: To observe the effect of high-intensity interval training on various clinical indicators of young obese patients with T2 DM,the efficacy and safety of high-intensity interval training were evaluated,so as to provide sequential therapeutic exercise for patients who was unsatisfactory to be treated by oral glucose-lowering drugs,or who expect to have a successfully intensive treatment after out of hospital.Method: To collect 64 young obese patients with T2 DM totally that met the inclusion criteria and the exclusion criteria from the Second Hospital of Jilin University from January 2018 to August 2019 were randomly divided into the experimental group and the control group,with 30 cases in each group,two groups of patients were given regular treatment such as oral metformin 0.5 mg TID,diet of diabetes mellitus,maintaining emotional stability,health education and so on,patients in experimental group exercised high-intensity intermittent training(HIIT)while others in control group exercised moderate intensity continuous training(MICT).The indicators were observed before treatment,at 12 weeks and 24 weeks in both groups as follows: fasting plasma glucose,2h plasma glucose,glycosylated hemoglobin A1 c,fasting insulin,triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,waist circumference,hip circumference,heart rate and rating of perceived exertion,calculating insulin resistance index,insulin sensitive index,body mass index and waist height ratio;patients' hypoglycemia,oral dose of metformin and other adverse reactions were recorded,and the incidence of hypoglycemia and drug reduction rate were calculated.Results: 1.There was no statistical difference in general clinical data and observation indicators between the two groups at the baseline(p> 0.05).2.FPG and 2h PG decreased in both HIIT and MICT groups compared with the baseline at each follow-up point(p<0.05).At 12 weeks,there was no significant difference in FPG,2h PG and Hb A1 c between the two groups(p>,0.05).At 24 weeks,the difference of FPG and Hb A1 c between the two groups was statistically significant(p<0.05).3.HOMA-IR in both HIIT and MICT groups decreased from baseline at all follow-up points(p<0.05).At 24 weeks,HOMA-IS increased in the HIIT group from baseline to 12 weeks(p<0.05),while HOMA-IS increased in the MICT group only showed statistically significant difference from the baseline(p<0.05).the decreasing HOMA-IR and increasing HOMA-IS in the HIIT group were better than those in the MICT group(p<0.05).4.TG and TC in HIIT group were lower than baseline at 12 weeks(p<0.05).In the MICT group,only TC decreased from baseline(p<0.05).Compared with the MICT group,the reduction of TG and TC in HIIT group was statistically significant(p<0.05).At 24 weeks,TC in HIIT group decreased from both baseline and 12 weeks,HDL-C was higher than that at baseline(p<0.05).In the MICT group,compared with the baseline,only TG and TC decreased(p<0.05).Compared with the MICT group,there were statistically significant differences in the reduction of TG and TC and the increase of HDL-C in the HIIT group(p<0.05).5.At 12 weeks,BMI,waist circumference,hip circumference and waist-height ratio decreased in HIIT group compared with baseline(p<0.05),while BMI,waist circumference and hip circumference decreased in MICT group from baseline(p<0.05).The reduction of waist circumference in HIIT group was better than that in MICT group(p<0.05).BMI and waist circumference decreased in the HIIT group at 24 weeks from both baseline and 12 weeks(p<0.05),while BMI and hip circumference decreased in the MICT group compared from both baseline and 12 weeks(p<0.05).Compared with MICT group,HIIT group in reducing BMI and waist circumference was better MICT group(p<0.05).6.Resting heart rates of both HIIT group and MICT group were lower than baseline at 12 weeks(p<0.05).At 24 weeks,HIIT group had no significant difference in resting rate,peak heart rate and RPE from 12 weeks(p>0.05),while MICT group had lower peak heart rate and RPE than 12 weeks(p<0.05).The comparison of resting rate,peak heart rate and RPE in the two groups at each follow-up point showed that HIIT group was higher than MICT group(p<0.05).7.Patients in both groups were followed up.1 patient from the HIIT group had some legs pain during exercise at 6 weeks,which was relieved after a rest.In both groups,2 patients developed diarrhea symptoms after taking metformin,which got better on their own without affecting life and exercise,and neither group showed exercise induced angina pectoris.8.At 12 weeks,there was no statistical difference in metformin reduction rate between HIIT group and MICT group(p>0.05).At 24 weeks,the reduction rate of metformin was higher in the HIIT group than that in the MICT group,but there was no significant difference between the two groups(p>0.05).There was no significant difference as well in the incidence of hypoglycemia between the two groups at 12 weeks and 24 weeks(p>0.05).Conclusion: 1.Compared with MICT,HIIT can significantly control blood sugar,improve insulin resistance,increase insulin sensitivity,reduce weight and regulate fat in young obese patients with T2 DM,and the effect is more significant over time.2.In this study,HIIT exercise from KEEP mobile phone software can reduce the dose of hypoglycemic drugs during the hypoglycemic process,which security is good,and provide a time-saving,convenient and effective exercise mode for young obese patients with T2 DM.