Association Of Apolipoprotein E Gene Polymorphism With Ischemic Stroke In Coronary Heart Disease Patients Treated With Statins

Objective:To study the association of apolipoprotein E(apoE)gene polymorphism with ischemic stroke(IS)in coronary heart disease(CHD)patients treated with medium-intensity statins.Methods:The retrospective study was performed on 662 samples,including 197 control subjects,297 CHD subjects and 169 CHD subjects complicated with IS.The apo E gene of control was obtained by texting and apo E gene of CHD and CHD + IS was obtained from case files.The type and dosage of statins used in CHD patients was collected by telephone interview,checking case files and outpatient prescription.Univariable and multivariable logistic regression analyses were utilized to recognize the possible risks of CHD and CHD + IS.Results:The frequency of ?3/?4 genotype was increased in CHD group(p = 0.013)and CHD + IS group(p = 0.001),the frequency of?4 allele was also increased in CHD group(p = 0.047)and CHD + IS group(p = 0.009)compared with control group.?3/?4 genotype was the independent risk for CHD and CHD + IS after adjusting for traditional risk factors with adjusted odds ratio(OR)1.939(95%CI 1.143-3.287,p =0.014)and adjusted OR 2.631(95%CI 1.496-4.626,p = 0.001).The ?4 allele was also significantly associated withCHD(adjusted OR 1.666,95%CI 1.079-2.572,p =0.021)and CHD + IS(adjusted OR 1.964,95%CI 1.228-3.124,p = 0.005).Conclusion:These results demonstrated that ?4 allele influenced the development of CHD with and without IS,espically for the genotype of ?3/?4.Even treated with medium-intensity statins,?3/?4genotype and?4 allele were also significantly associated with IS in CHD patients.