Establishment Of SD Rat Model Of Pigeon Feeder Lung And Its Pathological Manifestation

Objective: To establish a Sprague-Dawley rat(SD rat)model of the pigeon breeder’s lung and to compare the pathological performance of the lung model of pigeon breeder in different periods.Methods: 36 clean-level health SD rats were randomly divided into 2 groups,12 in the control group and 24 in the experimental group.Rats in the control group were atomized inhaled of 0.9% sodium chloride solution,in experimental group were atomized inhaled with freeze-dried powder solution which were made up by pigeon dung,feathers and dander.2hours a day,for a period of 16 weeks.At the 1th,2th,4th,12 th,14th week of intervention,3 rats were randomly selected from the experimental group to execute for their lung tissue samples.All rats were executed in week 16.Results: The pathological characteristics of acute period were observed in the first week,the pathological characteristics of subacute period were observed in weeks 2 to 14,chronic period performance in week 16.Results significant difference between the two groups of rat(P=0.000)with statistical significance.Conclusion: The freeze-dried powder solution which were made up of pigeon dung,feathers,and dander can establish SD rat models of pigeon breeder‘s lung,Pathological changes affirmation.