Effects Of Interleukin-10 On Proliferation And Collagen Synthesis In Cardiac Fibroblasts Of Sprague-Dawley(SD) Rats And Their Relations To Caidiac Remodeling

It has been proved that the left ventricular hypertrophy is a strong independent risk factor for the morbidity and mortality of essential hypertension.The proliferation of cardiac fibroblasts and the hypertrophy of myocardial cell is the vital pathophysilological bases which lead to left ventricular hypertrophy. Hypertensive myocardial frbrosis has been shown to facilitate ventricular dysfunction, diminished cornary reserve and ventricular arrhythmias that adversely affect the clinical outcome of hypertensive patients.How to improve and reverse left ventricular myocardial frbrosis has become the focus in the treatment of essential hypertension.Interleukin 10 (IL-10) is a recently identified anti -inflammatory cell factor,who can attenumate the systemic inflammatory response. In the present study ,someone demonstrate the inhibitory influence of IL-10 on TNF-α induced vascular smooth muscular cell.But the role of IL-10 in the pathological cardiac hypertrophy has not been clearly defined.And Whether IL-10 is effective in cardic interstitium is still obscure.The aim of this study was to evaluate the antiproliferative effects of IL-10...