| Background:As the change of natural environment and social environment,the occurrence of neonatal purulent meningitis showed a trend of increase year by year,in the early diagnosis and treatment of the disease in clinical work plays an key role in the prognosis of children,through the previous research,we found that in the occurrence of neonatal purulent meningitis,the incidence of premature fester sex meningitis was obviously higher than that of full term,the reason may be due to premature babies in the womb to develop completely,the failed to meet relevant function normal newborns,the adaptability of the external environment and lowered immunity,associated with increased risk of fester sex meningitis.In clinical work,the diagnosis and treatment for children with purulent meningitis has very mature,but some studies show that full term and preterm infants in the process of purulent meningitis by clinical features is not the same,it is especially important for early diagnosis and treatment,therefore,in order to further explore the full moon and neonatal purulent meningitis,the differences of clinical manifestations,we through the research of the difference of the related clinical manifestations were analysised retrospectively,to guide clinical work in the early diagnosis and treatment of neonatal purulent meningitis.Objective:To analyze and compare the clinical characteristics of premature infants and full-term infants in the process of purulent meningitis in Yichang,Hubei province.With a view to the early diagnosis and treatment of neonatal purulent meningitis in southwest China.Methods:A retrospective analysis of the three gorges university affiliated people's hospital of yichang city center from November 2014 to November 2019 collected 113 cases of children with neonatal purulent meningitis,including premature set for group A(19 cases),full term set for group B(94 cases),by comparing the preterm infants and full term gender,gestational age,onset age,birth weight,starting symptoms,cerebrospinal fluid,biochemical,cerebrospinal fluid cultivation,peripheral blood,peripheral blood infiammatory biomarkers,length of hospital stay,and outcome indicators such as the comparative analysis of the differences between two groups of children with clinical features.Results:Statistical analysis showed that there was no statistically significant difference in gender between group A and group B(P>.05).The difference in gestational age between group A and Group B was statistically significant(P<0.001),the gestational age of the children in group A was significantly lower than that in group B;There was no statistically significant difference in the age of birth at onset between group A and group B(P>0.05).The differences in birth weight between groups A and B were statistically significant(P<0.001),the birth weight of the children in group A was significantly lower than that in group B;There was no statistically significant difference in the first symptoms between group A and group B(P>,0.05).However,it was found that jaundice and convulsions were significantly higher than those with purulent meningitis in premature infants,while those with fever were lower than those with full term meningitis.There was no statistically significant difference between group A and group B in peripheral blood infection indexes(CRP and PCT)(P>0.05),but the ratio of infection indexes in term infants was significantly higher than that in premature infants,in addition,PCT sensitivity was significantly higher than CRP in all children.The content of sugar in the cerebrospinal fluid biochemical index in group A and Group B(P<0.05)and the number of nucleated cells(P<The difference was statistically significant(P>0.05),while the difference was not statistically significant(P>0.05).Through the culture of cerebrospinal fluid bacteria and peripheral blood bacteria in both groups A and B,the positive rates of cerebrospinal fluid and peripheral blood bacteria in the premature infants with purulent meningitis were significantly higher than those in the full-term infants with purulent meningitis.The difference in length of stay between group A and Group B was statistically significant(P<0.05);The hospitalization time of premature infants with purulent meningitis was significantly longer than that of infants with purulent meningitis.Through the statistical comparison of the mortality of children in group A and B,the mortality of children with purulent meningitis in premature infants was higher than that of children with purulent meningitis in term.Conclusion:In this study,we found that compared with the full-term infants with purulent meningitis,the incidence of premature infants with purulent meningitis was significantly lower in gestational age and birth weight.Among the first symptoms,convulsion and jaundice were the first common symptoms in premature infants with purulent meningitis,and fever was the first common symptom in full-term infants.Among peripheral blood infection indexes,the sensitivity of PCT in all children was significantly higher than CRP.In the CSF biochemical comparison,the content of sugar in CSF of premature infants was higher than that of term infants,but both of them were lower than that of normal newborns;At the same time,the number of nuclear cells in CSF of premature infants with purulent meningitis was significantly lower than that of term infants with CSF,but both of them were higher than that of normal newborns.Through the culture of cerebrospinal fluid and peripheral blood bacteria in newborn children with purulent meningitis,we found that the positive results of cerebrospinal fluid and peripheral blood bacteria culture in premature infants with purulent meningitis were significantly higher than those in infants with full-term purulent meningitis.Compared with the children with full-term purulent meningitis,the hospitalization time of the premature infants with purulent meningitis was significantly longer.Premature infants with purulent meningitis had a higher mortality rate than those with full-term meningitis. |
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