Effect Of Health Qigong Baduanjin On People With Mild Cognitive Impairment

Objective: To observe the effect of Health Qigong Baduanjin on cognitive function and non-cognitive function in people with mild cognitive impairment.Methods: Sixty-four patients with mild cognitive dysfunction in the neurology department and ward of Yueyang Hospital,as well as surrounding community(Quyang Street),were randomly divided into control group and Baduanjin exercise group by 1:1.Volunteers of control group received basic intervention(health education),and the Baduanjin exercise group was given an intervention exercise on the basis of the basic intervention for 24 weeks(at least 3 times a week,150 minutes a week).Cognitive function was assessed by the score of the Mini Mental State Examination(MMSE),the Montreal Cognitive Assessment Scale(Mo CA).The daily activity ability assessment used the Activities of Daily Living Scale(ADL),and the emotional assessment used the Depression Self-Assessment Scale(SDS)and the Self-rating Anxiety Scale(SAS).The general condition was assessed by the Global Recession Scale(GDS),and the exercise function assessment used the modified Rankin Scale(m RS).The TCM symptom assessment used the Dementia Syndrome Score Scale.Repeated measures analysis of variance was used for the measurement data in the observation indicators.If there was interaction between the analysis time and the group,MANOVA was used to analyze the individual effects.The discrete data or the count data was analyzed by the generalized estimation equation(GEE).When there was statistical significance,the LSD methodwas used to make a pairwise comparison.All statistical tests were two-sided,with a significant level of a=0.05,and P values ??were reported as accurate.Results:1.Impact on cognitive function:Impact on MMSE: The overall MMSE score in the Baduanjin exercise group improved over time(P< 0.001),with a significant improvement at the 12 th week(P= 0.046),and the control group did not change significantly over time(P= 0.760).There was no significant difference in the overall score of MMSE between the two groups at the 12 th week(P>0.05).At the 24 th week,the overall score of MMSE in the Baduanjin exercise group was significantly better than that in the control group(26.82 vs 25.29,P=0.003).In all areas of MMSE,only the memory field scores improved with time(P<0.001),and there was a significant improvement at the 12 th week(P=0.046).Other areas include time,orientation,spatial orientation,computational power,language and execution did not improve with time(P>0.05).There were no significant differences in all areas MMSE scores between the two groups at the 0th,12 th,and 24 th week(P>0.05).Impact on Mo CA: The overall score of Mo CA improved with time in both groups(P=0.043),and significantly improved at 24 th week compared with the 0th week and the12 th week(P=0.038,P=0.041),and the 12 th week.There was no significant improvement between the 0thweek and the 12thweek(P=0.315);there was no significant difference at each time point between the two groups(P>0.05).The Mo CA median spatial performance scores did not improve with time(P>0.05),but the other cognitive function scores based on memory improved with time,and the 24 thweek showed significant improvement compared with the 0th and 12 th weeks(P<0.001,P<0.001),and no significant improvement between the 12 th week and the 0th week(P=0.211);there was no difference at each time point between the two groups(P>0.05).In the various fields of Mo CA,memory and targeted fields of the two groups,and naming field of the control group changed with time(P<0.05).Other fields of two groups,including execution,naming,attention,language and abstract ability,and naming field of the Baduanjin exercise group did not change with time(P>0.05).At the0 th week,there were significant differences between the two groups(P=0.043),and no differences at the 12 thweek and the 24thweek(P>0.05).2.Impact on daily activity ability: The overall scores of ADL,and the scores of IADL and PSMS did not change with time(P>0.05);At the 0th week,12 th week and 24 th week,there was no difference between the two groups(P>0.05).3.Effects on feeling: The SDS scores of the two groups did not change with time(P=0.162),and the difference between the two groups was not statistically significant(P=0.068).The SAS score of the Badianjin group improved with time(P<0.001),and started to improve at the 12 th week(P=0.011);the SAS score of the control group did not change with time(P=0.828).There was no difference in SAS score between the two groups at the three observed points(P>0.05).4.Effects on general condition and exercise capacity: The GDS distribution of the two groups did not change with time(P=0.311),and the difference between the two groups was not statistically significant(P=0.920).There was no difference in the distribution of m RS between the two groups(P=0.561).There was no significant difference between the two groups(P=0.210).5.Impact on TCM syndromes: In the TCM syndromes of the MCI,the scores of the syndromes,including spleen and kidney deficiency syndrome and blood stasis syndrome in both two groups and brain deficiency syndrome in the control group were changed with time(P<0.05).Compared with the 0th week,there was a change at week12(P<0.05),but the change was not significant at the 12 th week and the 24 th week(P>0.05).The other syndromes in the two groups including qi and blood deficiency syndrome,phlegm syndrome,fire syndrome,and the toxic lesions of cerebral collaterals syndrome,and brain deficiency syndrome in the Baduanjin exercise group were not changed with time(P>0.05).There was no difference in the syndrome scores between the two groups at the three observation time points(P>0.05).In the syndrome of deficiency and filling symptoms,the scores of deficiency syndrome in the control group increased with time(P=0.006),and there was a change at the 12 th week(P=0.012).The changes in the 24 th week and the 12 th week were not significant,but there was an increasing trend(P=0.055);the scores of the deficiency syndrome of Baduanjin group did not change with time(P>0.05).There was no significant difference between the two groups at the 0th week and the 12 th week(P>0.05),but at the 24 th week,the score of the Badianjin group deficiency syndrome was significantly lower than that of the control group(11.57 vs 16.93,P=0.022).The scores of the two groups of filling syndrome did not change with time(P>0.05);the difference between the two groups was not statistically significant(P=0.112).Conclusion: Baduanjin exercise intervention for 24 weeks(At least 3 times a week,150 minutes per week)has a significant improvement on the overall MMSE score in patients with mild cognitive impairment,and has no significant effect on the Mo CA score,ADL,SDS,SAS,GDS,and m RS have no significant effect;there may be a two-way regulation of TCM symptoms adjusting deficiency and filling.