The Distribution Regularity Of TCM In Reflux Esophagitis And Clinical Observation On Treating Liver-Stomach Heat Syndrome With Jinwujiangni Self-Designed Prescription Combined With Rabeprazole

Objective:Collect 320 cases with reflux esophagitis corresponding to diagnosis standards,according to their clinical date,making an induction and analysis on the general demographic characteristics,pathogenesis related factors and clinical syndromes of TCM,discuss and summary clinical data correlation of reflux esophagitis and distribution regularity of TCM syndromes,In addition,the clinical effect of Jinwujiangni self-designed prescription combined with Rabeprazole was observed in patients with Liver-stomach Heat Syndrome in reflux esophagitis.Methods:1: Clinical data of patients diagnosed with reflux esophagitis by gastroscopy who went to the gastroenterology department of Tianjin university of traditional Chinese medicine from May2018 to November 2018 were collected and summarized to discuss the correlation of clinical data of reflux esophagitis and the distribution rule of TCM syndromes.2: Among the collected clinical data,the patients with reflux esophagitis whose syndrome differentiation of four-diagnosis combined with ginseng were Liver-stomach Heat Syndrome were selected according to the inclusion criteria.The cases were subdivided into 36 cases in therapy group and 37 cases in control group by random number table division.therapy group:Jinwujiangni self-designed prescription and Rabeprazole was given for treatment,Take one dosage a day,the decoction 200 m L was taken twice with lukewarm water,20 mg of Rabeprazole enteric capsules were taken orally once a day before breakfast;control group:20mg of Rabeprazole enteric capsules were taken orally once a day before breakfast,Trimebutin maleate tablets 0.2g,3 times daily.The course of treatment was 8 weeks in both groups,and the efficacy was determined after 8 weeks.Results:Research one:1.The incidence of reflux esophagitis is higher in men than women,and it builds up over age,rare in young groups.In terms of occupational distribution,the incidence rate of teachers,technicians and accounting personnel is higher than that of other occupations;the incidence of the disease is common in mild and moderate,grade A and B esophagitis accounts for more than90%.2.In the correlation between the pathogenesis factors,30.9% of patients with bmi index were overweight;patients who are accustomed to smoking,drinking and eating sweets are more likely to develop disease;overwork 、irregular diet and mood depression were more easily causing this disease;over half of patients have reflux symptoms,mostly are liquid reflux.The esophagitis is more serious,the number of the patients with poor cardiac is lager.HP infection may have a protective effect on patients with moderate to severe RE,and 36.6% of patients showed symptoms outside the esophagus,with pharyngitis being the most common.3.According to the distribution of TCM syndromes,Liver-stomach Heat Syndrome is the most common,followed by Gallbladder Heat Invading Stomach Syndrome,Spleen-Deficiency and Dampness-Heat,Qi-Phlegm Stagnation Syndrome,Spleen-Hypofunction and Reverse Qi Syndrome,and Qi Deficiency and Blood Stasis.Research Two:1.The total score of symptoms in two groups both were significant lower than that before treatment,and there was a statistical difference(P<0.05).2.After treatment,the total score of symptoms in therapy group was lower than that in control group,and there was a statistical difference(P<0.05).3.In the one-way symptom score,therapy group was less than control group in dry mouth,irritability,constipation,with statistical differences(P<0.05).4.In terms of clinical efficacy,the total effective rate of therapy group was 83.33%,control group was 70.27%,which was statistically significant(P<0.05).5.In terms of endoscopic efficacy,the total effective rate was 75.00% in therapy group and66.67% in control group,with no statistical difference(P>0.05).Conclusion:1.The incidence of reflux esophagitis is higher in men than in women,and the incidence rate increases with age,rare in adolescents.normal weight control is conducive to reducing the incidence.qiut smoking and alcohol,do not overwork,diet,control emotion is conducive to reducing the incidence of disease.Over half of patients have reflux symptoms,mostly are liquid reflux.The esophagitis is more serious,the possibility of the patients with poor cardiac is lager.HP infection may have a protective effect on moderate and severe patients,Patients who complain about pharyngitis should consider the possibility of reflux esophagitis.2.According to the distribution of TCM syndromes,Liver-stomach Heat Syndrome is the most common,followed by Gallbladder Heat Invading Stomach Syndrome,Spleen-Deficiency and Dampness-Heat,Qi-Phlegm Stagnation Syndrome,Spleen-Hypofunction and Reverse Qi Syndrome,and Qi Deficiency and Blood Stasis.3.Jinwujiangni self-designed prescription combined with Rabeprazole,Rabeprazole and Trimebutin maleate can improve the clinical symptoms of reflux esophagitis,and Jinwujiangni self-designed prescription combined with Rabeprazole is superior to Rabeprazole enteric-coated capsule and trimebutin maleate in clinical symptoms improvement and efficacy.4.Jinwujiangdi self-designed prescription combined with Rabeprazoleis superior to Rabeprazole and Trimebutin maleate in improving dry mouth,irritability,constipation.5.Jjinwujiangni self-designed prescription combined with Rabeprazole has the same effect as Rapeprazole and Trimebutin maleate tablets in improving the endoscopic efficacy.6.Rapeprazole combined with Trimebutin maleate have curative effect.