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Analysis Of The Factors Related To Hot Flashes Of Breast Cancer And The Intervention Of Traditional Chinese Medicine After Endocrine Therapy

Posted on:2021-04-26Degree:MasterType:Thesis
Country:ChinaCandidate:F G MaFull Text:PDF
GTID:2404330647955600Subject:Internal medicine of traditional Chinese medicine
Abstract/Summary:PDF Full Text Request
Objective: 1.The purpose of this study is to analyze the distribution of T-lymphocyte subsets and NK cells in breast cancer patients with different clinical characteristics,and to explore the related factors affecting the immune status of breast cancer patients after operation;2.To explore the effect of Jianpi Yiqi Decoction on improving the immune status,clinical symptoms of traditional Chinese medicine and quality of life of breast cancer patients after operation,and to analyze its clinical efficacy and safety,so as to provide reference for clinical practice In order to explore a better treatment.Methods: The first part: collect the patients after breast cancer surgery in the First Affiliated Hospital of Tianjin University of traditional Chinese medicine from September 2018 to February 2019,collect the age,pathological type,molecular typing,Ki67 value,lymph node metastasis and other clinical characteristics of the patients,and analyze the T-cell subsets and NK cell distribution of the patients with the above different clinical characteristics.The second part: according to the acceptance and exclusion criteria of clinical research,60 cases of breast cancer patients with postoperative immune function decline who are in line with the Western diagnosis of "breast cancer" and "spleen deficiency syndrome" of traditional Chinese medicine were randomly divided into the experimental group and the control group for different means of intervention treatment.30 cases in the control group were given basic treatment without drugs affecting the immune function;30 cases in the treatment group were given basic treatment while taking Jianpi Yiqi Decoction,and the drugs were added and subtracted according to the specific clinical symptoms and signs of the patients.After two courses of treatment,the improvement of T-lymphocyte subsets,quality of life and clinical syndromes of traditional Chinese medicine were compared before and after treatment.Results: The first part: according to the standard of sample intake and discharge,120 patients were included in the study.Through statistical analysis,the distribution of T-lymphocyte subsets and NK cells in breast cancer patients after operation was affected by some clinical characteristics: compared with the young group,the CD4+ value in the old group was(34.09±10.89 vs 41.42±13.69)(P<0.05),the difference was statistically significant;in molecular typing,the CD8 + value of luminal type was significantly higher than that of non luminal type(26.83±11.02 vs 21.35±9.77)(P<0.05),the difference was statistically significant;the CD3+ value(63.48±13.01 vs 69.48±11.12),NK value(8.87±5.41 vs 13.49±10.69)(P<0.05),the difference was statistically significant between the group with lymph node metastasis and the group without metastasis,while the pathological type of breast cancer and the increment of Ki67 had no significant effect on T-lymphocyte subsets and NK cells.The second part:according to the acceptance and exclusion criteria of clinical research,60 patients were collected.The general conditions and disease treatment of the two groups were comparable before treatment.The results showed that the treatment group was better than the control group in improving the quality of life and clinical symptoms of TCM in patients with spleen deficiency after breast cancer surgery(P<0.05);in terms of T-cell subsets and NK cells,2patients were treated After the course of treatment,the values of CD3+,CD4+,CD4+ / CD8+and NK cells in the experimental group were significantly higher than those before the treatment(P<0.05);the T-cell subsets and NK cells in the control group were higher,but the difference was not statistically significant;the values of CD3+ and CD4+ in the experimental group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05);during the treatment,the two groups Liver and kidney function,blood routine test and ECG showed no adverse conditions.Conclusion:(1)The immune function of patients with breast cancer after operation is affected by some clinical features: age,molecular typing and whether there is lymph node metastasis will affect T-lymphocyte subsets and NK cells,while pathological type and Ki67 proliferation will not directly affect T-lymphocyte subsets and NK cells.(2)Jianpi Yiqi Decoction can improve the immune function of patients,improve the anti-tumor ability of the body.(3)Jianpi Yiqi Decoction can significantly improve the symptoms of spleen qi deficiency in patients with breast cancer after operation,such as little appetite,abdominal distention after eating,body fatigue,mental fatigue and lazy speech.(4)Jianpi Yiqi Decoction plus basic treatment and simple basic treatment can improve the quality of life of patients,but traditional Chinese medicine treatment has more advantages.(5)Jianpi Yiqi Decoction did not appear abnormal blood routine,liver and kidney function,ECG and other examination during the study.The patients had good tolerance and high clinical efficacy and safety.
Keywords/Search Tags:Breast cancer, Immune state, Relevant factors, Quality of life, Deficiency of spleen qi, Jianpi Yiqi Decoction
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