Clinical Research Of Jianpi Xiaozhang Fang Applying To Shenque Point On Gastrointestinal Dysfunction In Sepsis

Purpose: Intervention of patients with gastrointestinal dysfunction of sepsis using Jianpi Xiaozhang Fang umbilical paste,Monitoring gastrointestinal function indicators,gastrointestinal function-related scores,and inflammatory indicators,etc.Initially explore the clinical efficacy of Jianpi Xiaozhang Fang umbilical paste for the treatment of disease.Methods: From July 2017 to February 2019,inpatients in the EICU,80 patients who met the inclusion criteria,were divided into intervention group and control group by random and controlled principles.Forty patients in each group,on the basis of routine treatment of western medicine,the intervention group using Jianpi Xiaozhang Fang umbilical paste,The another group received routine western medicine treatment.Perfecting basic information,APACHE II score and SOFA score,etc.IFABP,D-LAC levels,inflammatory markers(WBC,CRP,PCT),gastrointestinal dysfunction score,abdominal circumference,bowel sounds,etc.were recorded before and after intervention.Statistical analysis was performed using SPSS 21.0.Results:1 Basic information Baseline data such as age,gender,mechanical ventilation,underlying disease,APACHE II score,SOFA score,and IAP before intervention were no significantly different among two groups(P>0.05),which was comparable.2 Intervention of Jianpi xiaozhang Fang on various indicators2.1 Abdominal circumference,bowel sounds,IAP There were significant differences in abdominal circumference,bowel sounds and IAP between the two groups after intervention(P<0.01).The differences in abdominal circumference,bowel sounds and IAP between the two groups were statistically significant before and after intervention in treatment group(P<0.01),there was no significant difference in the control group(P>0.05).In the treatment group,the abdominal circumference was reduced,the IAP was decreased,and the bowel sounds were active.2.2 IFABP?D-LAC The difference about the serum IFABP levels between the two groups after the intervention was statistically significant(P<0.01).The Serum IFABP levels were decreased before and after intervention in both groups,and the difference was statistically significant(Treatment group P<0.01,control group P<0.05).The difference about the D-LAC levels between the two groups after the intervention was statistically significant(P<0.01).The difference about D-LAC levels before and after intervention in the intervention group was statistically significant(P<0.01),In another group was no statistically significant(P>0.05).2.3 The gastrointestinal dysfunction score and the SOFA score After the intervention,the difference about the scores between the two groups was statistically significant(P<0.01).There were significant differences between the two groups before and after intervention(P<0.05).The gastrointestinal dysfunction score and the SOFA score decreased in the treatment group.Greater than the control group.2.4 Evaluation of comprehensive efficacy The intervention group was effective in 32 cases and ineffective in 8 cases,the total effective rate was 80%;In another group,22 cases were effective and 18 cases were ineffective.The total effective rate was 55%;The two groups was statistically significant(P<0.05).2.5 The scores of TCM syndromes and efficacy evaluation The difference about the scores of TCM syndromes between the two groups after the intervention was statistically significant(P<0.05).There were significant differences in the scores of TCM syndromes before and after intervention in both groups(P<0.01).The total effective rate was 77.5% in the treatment group and 52.5% in another group after intervention.The two groups was statistically significant(P<0.05).2.6 Prognosis There were significant difference in the incidence of MODS between the two groups(P<0.05).There was no significant difference in the hospitalization days between the two groups(P>0.05).Conclusion: The use of Jianpi Xiaozhang Fang umbilical paste to interfere with patients with gastrointestinal dysfunction of sepsis,the clinical symptoms such as abdominal distension,abdominal pain,fatigue,constipation,etc,were significantly improved.Reduced serum IFABP and D-LAC levels to a certain extent,barrier function and ischemia and hypoxia have been improved,enhancing gastrointestinal motility.And the umbilical paste in the clinical operability is strong,the indications are wide.