Research On The Correlation Between TCM Syndromes Of Chronic Hepatitis B And Laboratory Indicators

Purpose:Through a retrospective study of patients with chronic hepatitis B,to understand the distribution of syndrome types of the disease,and to explore the relationship between TCM syndrome types of the disease and various physical and chemical indicators,in order to provide a basis for TCM syndrome differentiation and treatment of patients with chronic hepatitis B Material and method:To retrospectively study the methods of clinical cases by collecting the data of liver disease outpatients from January 2016 to December 2018 in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.The diagnostic criteria of TCM syndromes of the patients were classified into five syndromes: damp-heat internal node,liver depression and spleen deficiency,liver and kidney yin deficiency,blood stasis blocking collaterals,spleen and kidney yang deficiency according to the TCM syndrome differentiation criteria of viral hepatitis formulated by Hepatobiliary Disease Branch of Chinese Medical Association in 2017.Western medicine diagnostic criteria refer to the guideline of chronic hepatitis B prevention and control(updated version 2015).The inclusion criteria and exclusion criteria were used to screen the cases,and 239 cases were selected as the subjects of this retrospective analysis.The patients' gender,age,family history and related physical and chemical examinations were analyzed by SPSS22.0 statistical software.Chi-square test was used for counting data,and one-way ANOVA was used for measuring data with normal distribution and homogeneous variance.Otherwise,non-parametric test was used for counting data with normal distribution,and the measurement data with normal distribution was expressed by mean-standard deviation.When P < 0.05,it was statistically significant,P > 0.05 indicates no statistically significant difference.Results: 1.239 patients with chronic hepatitis B were divided into five syndrome types,of which 33% were liver depression and spleen deficiency syndrome,30% were damp-heat syndrome and less than 15% were other syndrome types.2.There is a correlation between the types of TCM syndromes and gender and age.The number of male patients with damp-heat syndrome was significantly higher than that of female patients.The age of patients with liver depression and spleen deficiency syndrome and damp-heat internal node syndrome is smaller than that of patients with liver and kidney yin deficiency,blood stasis and collateral obstruction,and spleen and kidney yang deficiency.There was no significant correlation between TCM syndromes and family aggregation of chronic hepatitis B.3.The correlation between TCM syndromes and laboratory indicators.The mean values of HBeAg,HBV-DNA,ALT,AST,GGT,ALP,TBIL,DBIL and IBIL in patients with damp-heat syndrome were higher than those of other syndromes.The mean values of HBeAg,HBV-DNA,ALT,AST,GGT and ALP in patients with liver-depression and spleen-deficiency syndrome were lower than those of other syndromes;the mean values of ALB in patients with spleen-kidney-yang deficiency syndrome were lower than those of other syndromes;the mean values of PTA in patients with damp-heat syndrome were lower than those of other syndromes.However,there was no statistical significance between each syndrome type and TBIL,DBIL,IBIL,GLOB,A/G,CHE.Conclusion: 1.Liver depression and spleen deficiency syndrome and damp-heat syndrome are the most common types of chronic hepatitis B patients.2.TCM syndromes of patients with chronic hepatitis B are closely related to age,HBeAg negative and positive,HBV-DNA viral load,ALT and AST.It has been preliminarily verified that it is feasible to quantify TCM syndromes with corresponding indicators in patients with chronic hepatitis B.However,more research is needed to support the exact relationship between syndrome types and laboratory tests.