Observation On The Clinical Efficacy Of Liqi Tongfu Runchang Granules In The Treatment Of Functional Constipation Of Intestinal Qi Stagnation

Purpose: To observe the clinical effect of "li qi tong fu runchang granules" formulated by professor jiang shumin on intestinal functional constipation,evaluate its clinical value,and explore its mechanism of action.Material and method: From the outpatient clinic of professor jiang shumin from the affiliated hospital of liaoning university of traditional Chinese medicine from2017-10 to 2019-10,98 patients with functional constipation who met the inclusion criteria with complete data and no organic changes in the intestinal tract were selected and randomly divided into treatment group and control group,49 cases in each group.In the treatment group,li qi tong fu runchang granules was given orally,while in the control group,lactin solution was given orally.The course of treatment was 4weeks.During the study,2 unqualified cases were excluded(1 patient in the treatment group automatically dropped out during the treatment,and 1 patient in the control group took other drugs during the trial).Therefore,a total of 96 cases were completed and well documented,including 48 in the treatment group and 48 in the control group.The scores of primary constipation,secondary constipation and total constipation before and after treatment of the two groups of patients were recorded,the clinical efficacy and safety of the two groups were evaluated,and the patients who recovered clinically,showed significant effect and were effective were visited 2months after the end of the course of treatment,and the long-term efficacy of the two groups was compared.Results:1.There was no significant difference in age,gender and course of disease between the two groups before treatment(P>0.05).2.After treatment,the scores of primary symptoms,secondary symptoms and total scores of constipation were significantly lower in both groups than before treatment(P < 0.05),and the mean scores of constipation in the treatment group were lower than that in the control group(P < 0.05).3.In terms of clinical efficacy after treatment,8 cases were cured clinically in the treatment group,19 cases showed significant effect,17 cases were effective,4cases were ineffective,and the total effective rate was 91.67%.In the control group,there were 2 cases of clinical recovery,7 cases of obvious effect,28 cases of effective,11 cases of ineffective,and the total effective rate was 79.17%.The difference of efficacy distribution between the two groups was statistically significant(P < 0.05).4.In terms of long-term efficacy,5 patients in the treatment group relapsed 2 months after drug withdrawal,and 39 patients did not relapsed,with a recurrence rate of11.36%.In the control group,there were 16 relapses and 20 did not,with a recurrence rate of 44.44%.The long-term efficacy of the treatment group was significantly better than that of the control group(P < 0.05).5.In terms of safety,no obvious discomfort or adverse reactions were found in all subjects,proving that the two groups of drugs were safe.Conclusion:Preliminary studies showed that li qi tong fu runchang granules and lactin oral solution could improve the symptoms of intestinal functional constipation,and were safe and effective.The curative effect of li qi tong fu runchang granules on the functional constipation of intestinal qi stagnation is definite,the effect is better than the oral solution of lactofructose.