Research On TCM Syndromes Of Rheumatoid Arthritis With Coronary Heart Disease

Purpose:Collect the distribution of disease location and disease syndrome of patients with rheumatoid arthritis(RA)combined with coronary heart disease(CHD),and analyze the relationship between disease syndrome and general data,symptoms and signs and laboratory indicators Correlation to guide clinical treatment based on syndrome differentiation.Material and method:A total of 312 patients with RA and CHD who were hospitalized from the affiliated hospital of Liaoning University of Traditional Chinese Medicine were collected.The basic data(gender,age,course of disease)of the patients,and TCM data(t CM diagnosis,syndrome,tongue and vein)related signs(joints)were collected.Swelling,joint tenderness),physical and chemical indicators(RF,anti-CCP antibodies,ESR,CRP,Ig A,Ig G,Ig M,complement C3,complement C4,TG,TC,HDL-C,LDL-C)and DAS28 scores,etc.,After finishing the induction,a database was established,and statistical analysis was performed using statistical methods to draw conclusions.Results:1.General information: Of the 312 subjects,39 were male(12.5%)and 273 were female(87.5%).The ratio of male to female is 1: 7,and there are more females than males;60 patients(19.2%)are under 60 years old,and 252(80.8%)are over 60 years old,and most of them are elderly patients.2.Distribution of disease sites: the overall distribution of disease sites is mainly in the kidney(199 cases,63.8%),followed by the heart(147 cases,47.1%)and liver(135cases,43.3%);The largest number of patients(156 cases,50.0%)were mainly hepatorenal disease(38 cases,12.18%),followed by the three disease position combination(87 cases,27.9%),with heart + liver + kidney being the majority(24cases),7.7%).3.Distribution of disease-related syndromes: The overall distribution ofdisease-related diseases is the most common with blood stasis(214 cases,68.6%),followed by phlegm(207 cases,66.3%),cold syndrome(101 cases,32.4%);The three-disease combination was the most,followed by the two-disease combination.Among the three-disease combination,qi deficiency + yin deficiency + blood stasis was the most(51 cases,16.35%).The two-disease combination was mostly phlegm +fiery fever(36 Example,11.54%).4.Correlation study of each disease syndrome with general information,related signs and laboratory tests: There is no statistics between each disease syndrome and patient age,joint swelling,joint tenderness,DAS28 score,RF,immune function The scientific significance(P>0.05);the disease syndrome "blood deficiency,fiery fever,yin deficiency" and ESR had statistical significance(P<0.05),"Wind syndrome,blood deficiency,fiery fever" was statistically significant with CRP(P <0.05),"qi stagnation,blood stasis,phlegm dampness" was statistically significant with anti-CCP antibodies(P <0.05),"blood stasis,phlegm "Damp and hot" had statistical significance with TC(P <0.05).Conclusion:1.RA patients with CHD were more common in elderly women.2.The disease is more common in kidney,heart and liver,and the disease is more common in blood stasis,phlegm and cold syndrome.3.Pathogenic syndromes are related to ESR and CRP,and patients with "blood deficiency,wind syndrome,and heat" syndromes are more severely ill.4.Pathogenic syndromes are related to anti-CCP antibodies and TCs.Among them,patients with "qi stagnation,blood stasis,phlegm and dampness" syndrome have higher anti-CCP antibody values and those with "blood stasis,phlegm and fever" are Patient TC value is higher.