Ankylosing Spondylitis, Cold And Heat Syndromes, Depression State Distribution And Correlation Analysis

OBJECTIVE:Based on clinical data collection,the distribution and correlation of cold and hot syndrome and depression state of ankylosing spondylitis(as)were studied,and the relationship between as syndrome,emotional state and disease characteristics was discussed,so as to provide theoretical basis for further improvement of as treatment plan.METHODS:192 patients with ankylosing spondylitis from July 2017 to December 2019 in the Department of Rheumatology of traditional Chinese medicine in China-Japan Friendship Hospital were enrolled in this study History,religious belief and other relevant information.Spss21.0 statistical software was used for statistical analysis.Binary logistic regression analysis,chi square test and independent sample T test were used to analyze the distribution and correlation of cold and heat syndrome and depression state.RESULTS:a total of 192 patients with ankylosing spondylitis were included in this study,including 137 male patients(71.4%)and 55 female patients(28.6%).The male to female ratio was 2.5:1;the age distribution was between 13 and 64 years old,with an average of(34.30±10.37)years old;the BASDAI score range was 0-8.6,with an average of(3.30±1.95).There were 170 cases(88.5%)of HLA-B27(+)and 22 cases(11.5%)of HLA-B27(-);92 cases(45.7%)of cold syndrome patients and 100 cases(54.3%)of heat syndrome patients;67 cases(34.9%)of depressive state patients and 125 cases(65.1%)of non depression state patients were diagnosed by CES-D score≥16.1.Comparison of emotional state and disease characteristics between kidney deficiency and Du cold group and kidney deficiency dampness heat group:the gender distribution difference between kidney deficiency and dampness heat syndrome was statistically significant(P=0.039),and the difference of depression state was statistically significant(P=0.039)=There was no significant difference in age,course of disease,BMI,BASDAI,BASFI,pain index,night pain,HLA-B27,family history,marital status and religious belief.2.Comparison of disease characteristics among different emotional states:there were statistically significant differences in BASDAI score(P=0.001)and nocturnal pain(P=0.004)between depression group and non depression state group,but there was no significant difference in age,course of disease,gender,BMI,BASDAI,BASFI,pain index,HLA-B27,family history,marriage history and religious belief.3.The distribution of depression in different TCM Syndromes of as patients:there was significant difference in emotional state between kidney deficiency and dampness heat syndrome(P=0.003),and there was significant difference in nocturnal pain between depression group and non depression state group in kidney deficiency and Du cold syndrome group(P<0.05)=There was no significant difference in age,gender,course of disease,BASDAI,BASFI,pain index,marital status,BMI,family history,religious belief,etc.There were significant differences in nocturnal pain(P=0.015)and BASDAI(P=0.003)between the depressive state group and the non depression state group in the kidney deficiency dampness heat syndrome group,but there were no significant differences in age,gender,course of disease,BASFI,pain index,marital status,BMI,family history,religious belief and so on.4.Comparison of TCM syndromes and disease characteristics in different genders:TCM syndrome(P=0.034),age(P<0.001),BASDAI score(P=0.017)and marital status(P<0.001)between male and female as patients=There was no significant difference in depression status,course of disease,BMI,BASFI,pain index,night pain,HLA-B27,family history and religious belief.5.Logistic correlation analysis of depression,TCM syndrome and other disease characteristics:BASDAI,nocturnal pain,kidney deficiency and Du cold syndrome were significantly correlated with depression(all P<0.05).After adjusting for age and gender,BASDAI,pain index,nocturnal pain,kidney deficiency and Du cold syndrome were significantly correlated with depression(all P<0.05).CONCLUSION:the depression rate of patients with ankylosing spondylitis is about 34.9%,which is significantly higher than that of normal people;there are differences between kidney deficiency and dampness heat syndrome;the depression rate of kidney deficiency and Du cold syndrome is higher than that of kidney deficiency damp heat syndrome;BASDAI,pain index,night pain,kidney deficiency and Du cold syndrome are significantly correlated with depression(all P<0.05).In the treatment of ankylosing spondylitis,actively control and relieve pain,reduce disease activity,or improve the emotional state of as patients,which has a positive impact on disease treatment;at the same time,in the process of TCM syndrome differentiation and treatment,fully consider the change of emotional state of as patients,give drug intervention or emotional care in treatment,directly improve the emotional state of patients,and at the same time,may have a positive impact on the treatment of primary diseases To help.