The Relationship Between Serotonin Transporter Gene And Guilt And Prosocial Behavior Under The Gene-environment Interaction

Prosocial behavior is an important theme of psychological research and an important aspect of individual social development.It is also of great significance to college students'interpersonal relationship,physical and mental health.It is acknowledged in psychology that the outcome of human development is determined by the interaction of genetic and environment.In recent years,the development of molecular genetics technology has provided technical support for the study of the impact of gene-environment interaction on human development results.In this study,5-HTTLPR was set as candidate gene and family environment as environmental variable to investigate the effect of 5-HTTLPR and family environment on guilt and prosocial behavior,and to further test accords with Diathesis-Stress Model,Differential Susceptibility Model or Vantage Sensitivity Model.The subjects of the study were 613 healthy and unrelated college students.With the informed consent,First,the oral mucosa cells were collected for DNA extraction and genotyping.Second,the Chinese version of family environment scale(FES-CV),self-conscious emotion scale(TOSCA-3)and prosocial behavior tendency scale were used to measure the indicators of family environment,guilt and prosocial behavior.The main results were as follows:1)there was no significant difference between 5-HTTLPR and college students' guilt and prosocial behavior.2)female college students with the L allele showed lower prosocial behavior in the family environment with low intimacy,but no significant difference in prosocial behavior in the family environment with high intimacy,which was not found in male college students.3)female college students with the L allele showed more guilt in families with high ambivalence,while the difference in guilt in families with low ambivalence was not significant,which was not found in male college students.In summary,5-HTTLPR has no direct effect on college students' pro-social behavior and guilt.The interaction between 5-HTTLPR and family environment(intimacy,conflict)on female college students' prosocial behavior and guilt is consistent with the Diathesis-Stress Model.