| Both parenteral lipid dose and fatty acid (FA) composition have been proposed as risk factors for neonatal intestinal failure associated liver disease (IFALD). This research compared conventional lipid (IntralipidRTM, n-6FA), dosed both high (10 g/kg/d) and low (5 g/kg/d), to fish oil (OmegavenRTM, n-3FA), dosed low (5 g/kg/d), in neonatal piglets at risk of IFALD. Piglets were given iso-nitrogenous TPN for 14 days and compared to sow fed controls. Outcome measures included bile flow, total body and brain weight. Bile flow was increased with fish-oil treatment and lowered with high dose IntralipidRTM (p < 0.05) while not different between low dose IntralipidRTM and controls. All TPN groups weighed less than controls (p < 0.05). Both low dose treatments were associated with reduced brain weight compared to the other groups (p < 0.05). These findings suggest that while low dose lipid treatments reduce the risk of developing IFALD, growth in neonates may be compromised. |
