| It is well known that Quillaja saponins have the ability to elicit a strong immune response when used as an adjuvant in an ISCOM matrix. However, to date, the antiviral capability of Quillaja saponins has not been documented. Using extracts from the Chilean Soap Bark Tree (Quillaja Saponaria Molina) we document the anti-viral capacities of Quillaja saponins against HSV-1 and Vaccinia. The saponin was ineffective against Vaccinia Virus, however neutralized HSV-1 in a time and temperature dependent manner. In addition, Quillaja Saponins were determined capable of preventing cell-to-cell spread when introduced in solution to cell monolayers. |
