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Controlling the mechanical properties of PVA hydrogels for biomedical applications

Posted on:2000-03-01Degree:M.E.ScType:Thesis
University:The University of Western Ontario (Canada)Candidate:Gordon, Melissa JoanneFull Text:PDF
GTID:2461390014465427Subject:Engineering
Abstract/Summary:
Poly(vinyl alcohol) (PVA) has been widely used in the medical field. However, a better understanding of the factors that control the mechanical properties of PVA is necessary to produce materials with consistent, repeatable mechanical properties for medical device applications. The use of sodium-montmorillonite nanoparticles to increase the overall strength of the PVA material was also investigated. The effects of PVA concentration, number of thermal cycles, thawing rate, and Na-montmorillonite concentration were investigated by analysis of the stress-strain and stress relaxation behaviour of the materials. All factors had a significant effect on the modulus of the material. The nanoparticles added in very small concentrations to the material were successful in increasing the modulus 2 to 3 times above the modulus of the corresponding PVA. The 15% PVA cycled 5 times at 0.1°C/min mimicked the mechanical properties of the porcine aortic root. Proposed applications of this material include artificial valve stents, vascular grafts, and vascular shunts.
Keywords/Search Tags:PVA, Mechanical properties, Material
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