| In this study, an accurate, selective, sensitive and nondestructive high performance liquid chromatographic (HPLC) method for the separation and quantitative determination of a mixture of some 1,4 benzodiazepines (namely Nitrazepam, Diazepam and Medazepam) was developed.;The method was found to be suitable for the determination of these compounds in proprietary drugs without suffering interferences from excepients. A recovery of 101.6%, an accuracy of ;Using the modified simplex algorithm, together with a suitable chromatographic response function (CRF), an optimum condition of 89% CH... |
