| Cancer is one of the most challenge diseases to treat around the world. Drug delivery system, as one of the chemotherapeutic treatments has received enorrmous attention from researchers. This thesis is to develop amphiphilic diblock copolymer protected nanoparticles loaded with anti-cancer drug, with small size and high drug loading, to achieve selective drug delivery using EPR effect. Chapter 1 briefly describes the motivation and novelties of this research pursuit. Chapter 2 introduces a modified confined impingement jets mixer with dilution (CIJ-D mixer), using flash nanoprecipitation to produce nanoparticles made of hydrophobic drugs. The CIJ-D mixer was evaluated by the sizes of &... |
