One-Step Synthesis Of Multifunctional Nanoparticles And Their Applications For Gas Sensing And Phototherapy

Cancer,with high incidence,high mortality and low cure rate,has become a major public health problem.Environment pollution is one of important factors lead to disease and cancer,which cannot be ignored.Therefore,the preparation of a sensitive,convenience sensing materials in environmental monitoring and develop a new cancer treatment research are great significance,which attracted the publics'and scientists'extensive attention.Based on this,a research on fluorescent sensor and cancer treatment are carry out in this thesis,the content is divided into the following three parts:(1)The synthesis and application of carbon dots,as well as the research progress of Prussian blue in biomedical applications are summarized.Moreover,the significance and research mentality of this article is put forward.(2)We present a one-step,low-cost preparative strategy for the synthesis of red-emitting CDs(RCDs)by a carbonization treatment of bagasse,a residue derived from sugar cane(Saccharum officinarum).The as-prepared RCDs were primarily characterized by transmission electron microscopy(TEM),Raman spectroscopy,Infrared spectra etc,and illustrated that as prepared RCDs were spherical nanoparticles with many functional groups on the surface,has a good graphene-like structure and the average size of the RCDs was determined to be about 3.6 nm.Fluorescence spectroscopy showed RCDs have a strong fluorescence emission.Further,the pristine RCDs have been coated on commercially available polyvinylidene fluoride(PVDF)membrane to construct a new solid-state fluorescence sensory material for vapor detection.The PVDF-loaded RCDs can instantly and expediently probe toxic ammonia gas with compelling selectivity as well as sensitivity.More importantly,the interfacial response occurring on the surface of the RCDs has been studied by X-ray photoelectron spectroscopy and Raman spectroscopy,and for the first time we clearly reveal the mechanism of the surface chemistry of CDs in the solid state.(3)We present a new and facile one-step method for the fabrication of a water-soluble hyaluronic acid(HA)modified prussian blue nanoparticles(PB@HA)as a nanoplatform for photodynamic therapy(PDT)and photo thermal therapy(PTT).Firstly,the results of transmission electron microscopy and dynamic light scattering was demonstrated that nanoparticles into cube,with hydrodynamic diameter around 81 nm.Secondly,the UV-vis spectroscopy and potothermal test in vitro showed that the synthesized PB@HA have obvious absorption at near infrared region,and it is efficiently converts light energy into heat under the NIR irradiation.What's more,PB@HA can efficiently produce reactive oxygen species(ROS)with NIR laser irradiation.In addition,the cytotoxicity experimental results showed that the synthesized PB@HA has very good biocompatibility.In vitro,PB@HA have been showed negligible cytotoxicity,and revealed that can selectively kill CD44-mediated cancer cells rather than normal cells via exposure to a NIR laser,which suggests that PB@HA can efficiently target tumor cells in PTT and PDT.