Design And Synthesis Of Copper Sulfide Nanomaterials And Its Potential Application In Photothermal Therapy Of Tumor

At present,malignant tumor is an important fatal disease facing human society,and its threat to human life and health ranks second among all diseases.However,traditional tumor treatment methods,including traditional therapies such as chemotherapy,radiation therapy,and surgical treatment,have various deficiencies,such as hair loss and drug resistance.These problems limit the clinical treatment effects of the above traditional therapies.Therefore,it is urgent to find a safe,efficient,and less side-effect treatment.With the rapid development of medicine in recent years,some new tumor treatment methods have been applied in the field of medical research and have played an extremely important role in tumor treatment.Among them,the application of photothermal therapy in the field of medical research has attracted widespread attention of scientific workers.It has the advantages of fast,efficient,accurate,and small side effects.The most important thing is that photothermal therapy is a local treatment method,which effectively avoids the mental and physical stress and injury caused by traditional therapies;the special shape of photothermal nanomaterials can also be used as drug carriers.Can effectively load and control the release of drugs,this photothermal-chemical combination therapy can achieve better killing effect on tumor cells,thereby achieving effective treatment of tumors.The synthesis of photothermal nanomaterials have become one of the important research hotspots in the field of nanomaterials.In this dissertation,copper sulfide nano-photothermal materials with different morphologies were synthesized using a green and mild water bath method and interface method.Copper sulfide nano-materials have high light-to-heat conversion efficiency,good biocompatibility,and are easy to functionalize.Advantage has become a research hotspot.It has exerted great potential in the fields of solar energy,photocatalysis,electrochemistry,etc.In recent years,photothermal nanomaterials have become the focus of scientific researchers in the field of biomedical research.This paper mainly studies the application of three different morphology of copper sulfide nanomaterials in photothermal treatment of tumors:(1)Using polyvinylpyrrolidone(PVP)as a soft template,copper sulfide nanoparticles with an average particle size of about 41 nm were synthesized through a water bath reaction.Cu S-PVP was tested to be more crystalline by different characterization methods Crystal nanoparticles,especially in the near-infrared region,show strong light absorption performance.Results of in vitro photothermal conversion performance tests show that the maximum temperature of copper sulfide nanoparticles increased to 55 ° C when exposed to 808 nm laser for 5 min.After 5 cycles,it shows good photothermal stability.The results of in vivo and in vitro experiments show that copper sulfide nanomaterials have a good killing effect on tumor cells,which provides its potential application in the field of clinical tumor photothermal treatment.Important support.(2)A liquid-liquid interface method was constructed using an inorganic aqueous phase and an organic ethyl acetate phase,and spherical copper sulfide was synthesized through an interface reaction.Through various characterization tests,spherical copper sulfide is a nanosphere formed by self-assembly of small particles and has a hollow structure inside.The results of in vitro photothermal conversion performance tests show that it has high photothermal conversion efficiency and light stability.We designed it.As a drug carrier,and then loaded with the anti-cancer drug DOX,as a dual-functional material,it shows high cell killing ability in anti-tumor cells,which provides important for the design and synthesis of multifunctional nano-drugs in anti-tumor applications in accordance with.(3)Using a mild water bath method,under the control of bovine serum albumin(BSA),a copper sulfide quantum dot with a particle diameter of 4.2 nm was synthesized.Through various characterization methods,the copper sulfide quantum dots were tested in visible to near infrared The region has a certain absorption capacity,and also has good fluorescence performance.In vitro photothermal conversion experiments show that the sample has a certain temperature rising ability and photostability at a certain concentration.Cell experiments show that the sample has good biological phase Capacitive,in photothermal tumor cell therapy,the data show that the sample has a certain killing ability at a certain concentration,which provides a good idea for tumor fluorescent labeling and tumor treatment.