Design And Synthesis Of Ruthenium Complexes With Near Infrared Absorption And Study On Photodynamic Therapy And Hydrogen Production From Photolysis Of Water

Ruthenium complexes containing polypyridyl ligands have excellent photophysical properties,and are widely used as photosensitizers or photocatalysts in the field of tumor photodynamic therapy(PDT)and photocatalysis.Through the design of the ligand structure,the excited state energy level and molecular orbital distribution of the ruthenium complex can be adjusted,thereby changing the absorption spectrum wavelength,emission spectrum wavelength,luminescence lifetime,etc.As a new type of cancer treatment method,PDT greatly reduces the damage of traditional chemotherapy drugs to normal cells.Near infrared light has good penetrability to the skin and is an ideal PDT wavelength.Therefore,the development of photosensitizers with near-infrared absorption wavelengths is a hot spot in the design and synthesis of PDT reagents.On the other hand,as a low-cost,non-polluting hydrogen production technology,hydrogen production from photolysis water is currently a hot spot in energy research.In the photolysis water hydrogen production system,the nature of the photosensitizer affects the hydrogen production efficiency.The ideal photosensitizer has good optical properties and photophysical properties,and has good absorption strength in the whole range of sunlight.The research focus of this paper is to design and synthesize ruthenium complexes with excellent visible-near-infrared absorption properties,and to explore their capabilities as PDT reagents and photolysis water photosensitizers.The first part briefly describes the following contents: 1)the general situation of cancer treatment,2)the research progress of PDT photosensitizer,3)the overview of hydrogen production by photolysis of water,and 4)the research progress of catalyst and photosensitizer.The practical application prospects of ruthenium complexes with near-infrared absorption in PDT therapy and photolysis of water to produce hydrogen are prospected.The second part introduces the synthesis and characterization of the designed ruthenium complexes,and studies of the properties of excited states through spectral and quantum chemistry theoretical calculations,which provides a theoretical basis for its application and mechanism as a photosensitizer.The third part introducesthe study of the properties of the synthesized complexes as potential PDT photosensitizers.In the fourth part,the properties of hydrogen production by a selected complex as photosensitizers,upon irridiation at different wavelength ranges,were studied.