Preparation Of Two Kinds Of Near-Infrared Light-Responsive Multifunctional Nanomaterials And Sdudy Of Their Antitumor Performance

Cancer is a serious threat to human life and health worldwide.Although the modern medical level has been developing rapidly,how to cure malignant tumors is still a problem that needs to be solved urgently.Traditional chemotherapy and radiotherapy are inefficient and can cause damage to normal tissues.New treatment methods are needed such as chemodynamic therapy(CDT),photodynamic therapy(PDT),photothermal therapy(PTT),etc.They have good therapeutic effects and selectivity,and have little side effects.In this paper,two near-infrared light-responsive multifunctional nanomaterials are prepared,which having multi-modal therapy and multi-modal imaging,and show excellent diagnostic and therapeutic effects in tumor diagnosis and treatment.The details are as follows:The Na Gd F₄:Yb,Tm@Na Gd F₄:Nd,Yb(UCNPs)were synthesized by high temperature pyrolysis method,and tin dioxide(Sn O₂)was coated on the core-shell conversion nanoparticles.And the Nd³⁺doping core-shell structured UCNPs could efficiently convert the NIR photons into ultraviolet(UV)light,which can further trigger Sn O₂ to produce reactive oxygen species(ROS)for photodynamic therapy.The mesoporous structure of UCNPs@Sn O₂can be loaded with the chemotherapy drug doxorubicin(loading rate is 47.2%).After high temperature generated by photothermal,it can accelerate the release of doxorubicin and enhance the effect of chemotherapy.UCNPs@Sn O₂-DOX/BSA was prepared after modification with bovine serum albumin(BSA)to make it have good water solubility and biocompatibility.Experimental results show that this nano-platform realizes chemotherapy,photodynamic,and photothermal multi-modal therapy,showing excellent anti-tumor effects.In addition,this platform is equipped with UCL,CT,and MRI three-modal imaging to realize the integration of tumor diagnosis and treatment.A glutathione-responsive Cu Mn Se₂@Ca O₂ nano-reagent with photothermal performance was prepared by high temperature pyrolysis method and hot solution injection method.Cu Mn Se₂@Ca O₂ can react with reduced glutathione to decompose to produce Cu⁺and Mn²⁺.Cu⁺acts as a Fenton-like reagent to generate hydroxyl free radicals and realize chemodynamic therapy.In addition,Cu Mn Se₂@Ca O₂,as a photothermal agent,has a strong absorption in the near-infrared region.On the one hand,the 1064 nm laser is used for photothermal treatment.On the other hand,the photothermal effect further enhances the curative effect of chemodynamic therapy,effectively killing cancer cells,and has excellent anti-cancer effect.The longitudinal relaxation(T₁)of the released Mn²⁺is conducive to magnetic resonance imaging(MRI)monitoring and observation,and has huge inherent potential in the field of tumor diagnosis and treatment.