Preparation And Properties Of Polycaprolactone Nanofiber-based Hydrogel Membrane

With the development of the national economy,people pay more and more attention to self-care,and facial mask products have become an indispensable part of the public.However,traditional facial masks generally have shortcomings such as poor skin fit,low absorption rate of functional substances.Research on the structure,composition and materials of facial masks has attracted more and more attention.Among the many new materials,electrospun nanofiber membranes have the advantages of high porosity,large specific surface area and controllable morphology,etc.Besides,it can transform functional substances into nanometers to achieve high absorption rate of the human body.It is widely used in the field of daily necessities.However,nanofiber membranes have problems such as poor adhesion and moisture retention.Combining it with hydrogel material that has high water swelling and good moisture retention can integrate the advantages of the two to prepare a mask material with excellent moisture retention,adhesion and adhesion.This subject uses environmentally friendly solvent electrospinning to prepare polycaprolactone(PCL)nanofiber membranes loaded with functional substances,and realizes the nanometerization of functional substances.Then it is combined with the hydrogels to prepare a nanofiber-based hydrogel membrane with excellent hydrophilic water retention,antibacterial properties,and biocompatibility,which solves the problems of the poor water retention and skin adhesion in the traditional mask material.The first part is the nanoization of functional substances.Through the environmentally friendly solvent electrostatic spinning process,the biodegradable polymer-PCL is used as the base material,the bio-based antibacterial agent-polypeptide(polylysine?-PL)and skin care agent-(allantoin)is introduced to prepare a new type of green nanofiber membrane.And the influence of spinning process and additives on the fiber structure and performance of the nanofiber membrane is further explored.The results show that the allantoin-loaded nanofiber membrane not only has a good morphology,but also has excellent mechanical properties,antibacterial properties and biocompatibility.And it has a good application prospect in the fields of facial masks,dressings and so on.The second part is aimed at the poor hydrophilicity,water absorption and adhesion of the PCL nanofiber membrane prepared in the previous part.On the basis of the preparation of the nanofiber membrane,the polysaccharide hydrogel is introduced to prepare the nanofiber-hydrogel composite membrane,which can improve many problems exist in nanofiber membranes.COS-OKGM hydrogels are prepared by Schiff base reaction using oxidized konjac glucomannan(OKGM)and chitosan oligosaccharide(COS)as raw materials.The COS-OKGM/PNM nanofiber/hydrogel composite membrane is prepared by physical compounding of the hydrogel system and PCL nanofiber membrane(PNM)with functional substance.We explore the influence of the introduction of polysaccharide hydrogels on the properties of PNM,such as water swelling,antibacterial,sustained release of functional substances,and biocompatibility.The results show that COS-OKGM/PNM has excellent water-absorbing swelling properties,self-healing properties,slow-release properties of functional substances,antibacterial properties and biocompatibility.And its antibacterial rate against Escherichia coli and Staphylococcus aureus is 99.99%;the cumulative release percentage of functional substances reaches 65.2%,which solves the problems of PNM poor adhesion and hydrophilicity.The third part is aimed at the problem of poor binding force between hydrogels and PNM.We use PCL nanofiber membrane as the base material,the natural polysaccharide COSMA and hyaluronic acid(HA)with good biocompatibility,degradability and biological activity are introduced to the surface of fiber by ultraviolet light-initiated graft modification,electrostatic adsorption and ion crosslinking method.The PCL-COSMA-HA-iron ion(Fe³⁺)nanofiber hydrogel membrane is prepared.The results show that PCL-COSMA-HA-Fe³⁺has excellent antibacterial,drug sustained-release properties and biocompatibility.At the same time,it is found that the cumulative release percentage of PCL-COSMA-HA-Fe³⁺can reach62%,which achieves an excellent slow-release effect of functional substances.And the grafting treatment of the PCL nanofiber membrane does not affect its excellent antibacterial and mechanical properties.PCL-COSMA-HA-Fe³⁺nanofiber membrane hydrogels solve the problem of poor physical bonding between hydrogels and nanofiber membrane.