Design And Development Of Implantable Drug Delivery System With Controllable Timing And Dosage

Implantable drug delivery can increase the local drug concentration and reduce the adverse reactions caused by systemic drug delivery.It has received great attention from researchers in recent years.Powered implantable drug delivery systems have Satisfactory drug delivery controllability,but their biocompatibility is poor.The development of non-powered implantable drug delivery systems with good biocompatibility has become a research hotspot in the field.Non-powered implantable drug delivery systems currently in commercial applications are mainly composed of alloys,liposomes,nanoparticles and other materials,which can only achieve simple sustained release,and drug delivery systems with good controllable release performance are in industrialization.There are still many difficulties in the process.Among them,the accuracy of drug delivery,the realization of in vivo sensing and control are key issues to be solved urgently.In this regard,this paper proposes a new non-powered implantable drug delivery system with controllable timing and dosage.The main research content and work include the following:1.A non-powered implantable precise and controllable drug delivery system solution design.A system solution of non-powered implantation and drug delivery including a drug-loaded device,a posture sensor module and a robot-assisted drive control module is proposed.The drug-loaded device is used for drug storage and release,the pose sensor module is used to detect the pose information of the drug-loaded device in the body to feedback the drug delivery state,and the robot-assisted driving and controlling module is used to drive and control the drug delivery device in vivo.2.Design and manufacturing of drug-loaded device.A drug loaded device composed of a core-shell structure drug-loaded capsule,a magnetic moving part and a supporting structure is designed.The drug-loaded capsules are filled in the capsule warehouse,and the magnetic moving parts are used for digital drug delivery by means of spatial addressing.The dosage,type and storage location of the drug can be preset to achieve precise control.The drug-loaded capsule and supporting structure are all made of biocompatible materials for light-curing 3D printing to complete the manufacturing.3.Construction and experimental verification of posture sensing module in vivo.The software and hardware platform of the in-vivo pose sensor module based on the magnetic dipole model is built;the five-dimensional pose information of the detected magnetic component is estimated through the steps of magnetic field strength reading,error filtering,and particle swarm algorithm solving;Simulation experiments,random point error experiments,and posture sensing experiments of drug-loaded device verify the feasibility of the posture sensing module.4.The construction and experimental verification of the robot auxiliary drive control module.A robot auxiliary driving and controlling module hardware platform composed of robots,driving permanent magnets,calibration rods,etc.A robot wireless controlling and driving software platform developed based on python-urx have been built.A driving control method including system calibration,driving target point calculation,and drug delivery status feedback was designed,and the magnetic driving experiment and in vitro drug delivery experiment proved that the driving control module can reliably complete the controllable release of the drug.5.The drug delivery system simulates the controllable release performance experiment of drugs.The effects of the material molecular weight,concentration ratio,and size of the drug delivery hole on the background diffusion of the drug-carrying device were studied,and the parameter combination was optimized for the controllable release of the drug.The experimental results show that there is no significant difference in cell proliferation between the experimental group and the control group,which proves the good biocompatibility of the drug delivery device;in the 7-day pulsating drug delivery experiment,the release amount in the driving mode is compared with that in the non-driving mode.The model was increased by 9.28 times,and the cumulative release amount maintained good consistency,which proved the accuracy and reliability of the drug delivery system;the imaging experiment proved the feasibility of in vivo drug delivery.