Uveitis Associated With Ankylosing Spondylitis In Clinical Features And Risk Factors

ObjectiveTo explore the clinical features and risk factors of ankylosing spondylitis(AS,Ankylosing spondylitis)with uveitis.MethodsA retrospective analysis of 80 patients with ankylosing spondylitis and uveitis in the First Affiliated Hospital of Zhengzhou University from July 2013 to July 2017(uveitis group)and AS patients without uveitis 234 Case(control group),explored the clinical characteristics and risk factors of patients with ankylosing spondylitis with uveitis.Results1.Finally,This study included 80 patients with AS complicated uveitis,and 234 patients with AS without uveitis in the uveitis group,27 cases(27/76,35.5%)with uveitis as the first manifestation.Patients in both groups were mainly male,with an average age of 38.00±14.31 years old.The ratio of male to female in the uveitis group was 68/12,5.7:1,and the ratio of male to female in the non-uveitis group was 171/61,2.8:1.Compared with the control group,there were more men in the uveitis group(P=0.046)and age Greater(P=0.016).Patients with AS with uveitis had more smoking history than the control group(26%vs 10.2%,P=0.008).In terms of joint involvement,the control group had more joint involvement than the uveitis group,and the hip joint and vertebral body were more affected(P<0.05).Patients in the uveitis group(average 0 years,range 0-3 years)had a shorter time from first symptom to AS diagnosis than the control group(average 0.41 years,range 0-4 years)(P=0.017).Most of the patients in the two groups were HLA-B27-positive patients,but there was no significant difference in the positive rate of HLA-B27 between the two groups(P=1).There was no difference in fever symptoms and family history of AS between the two groups(P>0.05).2.The levels of white blood cells(P=0.006),neutrophil count(P=0.002),and RPR(P=0.01)in the uveitis group were higher,and the differences were statistically significant;the uveitis group was hypoalbuminemia,alkalinity The levels of sex phosphatase,eosinophils,and ESR levels were lower than those of the control group(P<0.05);compared with the control group,the uveitis group had a lower IgG level(P=0.04).The two groups had abnormal dyslipidemia and lymphocytes.Count,basophils,red blood cell distribution width,average platelet volume,ceruloplasmin,CRP level,NLR,PLR,SⅡ and other indicators were not statistically different(P>0.05).3.Patients in the uveitis group were more likely to develop aortic insufficiency than the control group(P=0.049);the incidence of pulmonary hypertension and heart block was not statistically different from the control group(P>0.05).4.A logistic multivariate analysis of 9 independent variables including HLA-B27 positive,diagnosis delay time,WBC,NUET,ESR,NLR,PLR,RPR,and SII showed that HLA-B27 was positive(OR=10.072,95%CI=1.443-70.312,P=0.02),WBC(OR=2.295,95%CI=1.139-4.626,P=0.02),ESR(OR=0.978,95%CI=0.960-0.996,P=0.016),NLR(OR=3.096,95%CI=1.368-7.007,P=0.007)is an independent risk factor for AS associated with uveitis.The incidence of uveitis in patients with HLAB27-positive AS is 10.072 times that of HLA-B27-negative patients.WBC and NLR increase,the risk of uveitis in AS patients increases by 1.295 times and 2.096 times,respectively.5.ROC curve analysis of HLA-B27 positive,diagnosis delay time,WBC,NUET,ESR,NLR,PLR,RPR,SⅡ shows that AS patients are positive for HLA-B27,accompanied by NLR,PLR,RPR,SII,WBC When NEUT is elevated,the risk of uveitis is higher,the area under the curve is 81.3%,the specificity is 84.52%,and the sensitivity is 70.27%.Conclusion:Positive HLA-B27,elevated WBC,ESR,and NLR are independent risk factors for AS with uveitis.AS patients who are HLA-B27 positive and have elevated NLR,PLR,RPR,SII,WBC,and NEUT are at higher risk of uveitis.